# Distinguishing Early Depression from Negative Emotion via Multi-Domain EEG Feature Fusion and Multi-Head Additive Attention Network

**Authors:** Ruoyu Du, Benbao Wang, Haipeng Gao, Tingting Xu, Shanjing Ju, Xin Xu, Jiangnan Xu

PMC · DOI: 10.3390/e28020218 · 2026-02-13

## TL;DR

This paper introduces a neural network framework using EEG signals to distinguish early depression from negative emotions, offering a more objective diagnostic tool.

## Contribution

A novel lightweight neural network with multi-head additive attention for EEG-based depression detection, outperforming existing methods.

## Key findings

- The proposed model achieves 92.2% accuracy and 93% F1-score in distinguishing depression from negative emotions.
- The framework outperforms baseline SVM and standard deep learning approaches in classification performance.
- The model is computationally efficient and suitable for real-time mental health monitoring.

## Abstract

The early diagnosis of depression is often impeded by the subjectivity inherent in traditional clinical assessments. To advance objective screening, this study proposes a lightweight neural network framework designed to discriminate between pathological depressive states and non-pathological transient negative emotions using EEG signals. Diverging from conventional methods that rely on single-domain features, we construct a comprehensive multi-domain feature space via Wavelet Packet Decomposition. Specifically, the framework integrates frequency (α/β power spectral density ratio), spatial (normalized α-asymmetry), and non-linear (Sample Entropy) attributes to capture the heterogeneous neurophysiological dynamics of depression. To effectively synthesize these diverse features, a multi-head additive attention mechanism is introduced. This mechanism empowers the model to adaptively recalibrate feature weights, thereby prioritizing the most discriminative patterns associated with the disorder. Experimental validation on the DEAP (negative emotion) and HUSM (major depressive disorder) datasets demonstrates that the proposed method achieves a classification accuracy of 92.2% and an F1-score of 93%. Comparative results indicate that our model significantly outperforms baseline SVM and standard deep learning approaches. Furthermore, the architecture exhibits high computational efficiency and rapid convergence, highlighting its potential as a deployable engine for real-time mental health monitoring in clinical scenarios.

## Linked entities

- **Diseases:** depression (MONDO:0002050), major depressive disorder (MONDO:0002009)

## Full-text entities

- **Genes:** FBXL15 (F-box and leucine rich repeat protein 15) [NCBI Gene 79176] {aka FBXO37, Fbl15, JET}, APP (amyloid beta precursor protein) [NCBI Gene 351] {aka AAA, ABETA, ABPP, AD1, APPI, CTFgamma}
- **Diseases:** Negative mood (MESH:D019964), fatigue (MESH:D005221), hyperactivity (MESH:D006948), neurological disorders (MESH:D009461), MDD (MESH:D003865), emotional disorders (MESH:D009358), tension (MESH:D018781), injury to (MESH:D014947), mental disorder (MESH:D001523), anxiety (MESH:D001007), negative emotion (MESH:D064726), Depression (MESH:D003866), hypersensitivity (MESH:D004342), rigidity (MESH:D009127), clinical disorder (MESH:D000075902), HUSM (MESH:D003428), lethargy (MESH:D053609)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

19 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12939544/full.md

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Source: https://tomesphere.com/paper/PMC12939544