# Mitochondria in the Crossfire: Cardiac Vulnerability During Chemotherapy

**Authors:** Teresa Pasqua, Maria Erika D’Alessandro, Nicola Amodio

PMC · DOI: 10.3390/cancers18040674 · 2026-02-19

## Full-text entities

- **Genes:** Top2b (topoisomerase (DNA) II beta) [NCBI Gene 21974] {aka D230016L12Rik, Top-2}, Trp53-ps (transformation related protein 53, pseudogene) [NCBI Gene 22060], Sirt1 (sirtuin 1) [NCBI Gene 93759] {aka SIR2L1, Sir2, Sir2a, Sir2alpha}, TOP2B (DNA topoisomerase II beta) [NCBI Gene 7155] {aka BILU, TOPIIB, top2beta}, Ppargc1a (peroxisome proliferative activated receptor, gamma, coactivator 1 alpha) [NCBI Gene 19017] {aka A830037N07Rik, Gm11133, PGC-1, PPARGC-1-alpha, Pgc-1alpha, Pgc1}, TOP2A (DNA topoisomerase II alpha) [NCBI Gene 7153] {aka TOP2, TOP2alpha, TOPIIA, TP2A}, SLC25A6 (solute carrier family 25 member 6) [NCBI Gene 293] {aka AAC3, ANT, ANT 2, ANT 3, ANT3, ANT3Y}
- **Diseases:** tumor (MESH:D009369), mitochondrial damage (MESH:D028361), injury to (MESH:D014947), cardiomyocyte damage (MESH:D020263), hematological malignancies (MESH:D019337), metabolic impairment (MESH:D008659), cardiotoxicity (MESH:D066126), cardiomyopathy (MESH:D009202), toxicity (MESH:D064420), mitochondrial collapse (MESH:D001261), cardiac dysfunction (MESH:D006331), heart failure (MESH:D006333)
- **Chemicals:** ANTs (MESH:D018943), iron (MESH:D007501), cardiolipin (MESH:D002308), phospholipid (MESH:D010743), dexrazoxane (MESH:D064730), Doxo (MESH:D004317), MTAs (-), ROS (MESH:D017382)
- **Species:** Mus musculus (house mouse, species) [taxon 10090], Homo sapiens (human, species) [taxon 9606]

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Source: https://tomesphere.com/paper/PMC12939420