# Invasive Mucinous Adenocarcinoma Presenting as Cavitary Lung Disease: A Case Report and Narrative Review

**Authors:** Anna Haymov, Mohammed Alsaggaf, Japleen Kaur

PMC · DOI: 10.7759/cureus.102395 · Cureus · 2026-01-27

## TL;DR

A rare lung cancer case mimicked infection, highlighting the difficulty in diagnosing cavitary invasive mucinous adenocarcinoma.

## Contribution

Presents a unique case of IMA with cavitary lung lesions and emphasizes diagnostic challenges in non-smokers.

## Key findings

- IMA can present as cavitary lung disease, resembling infections or inflammation.
- Delayed diagnosis occurred due to non-specific symptoms and negative initial tests.
- Surgical biopsy was necessary for a definitive diagnosis in this case.

## Abstract

Invasive mucinous adenocarcinoma (IMA) is a rare subtype of lung adenocarcinoma that often presents with non-specific or misleading radiographic findings. We report a case of a 71-year-old female patient, non-smoker, who presented with progressive dyspnea on exertion and chronic cough unresponsive to multiple antibiotic regimens. Imaging revealed bilateral cavitary lung lesions. Comprehensive infectious and autoimmune evaluations, including bronchoscopy with bronchoalveolar lavage, were negative, and transbronchial biopsy was non-diagnostic. A surgical lung biopsy ultimately confirmed IMA. This case underscores the diagnostic challenges posed by cavitary IMA, which may resemble benign infectious or inflammatory processes, particularly in patients without conventional risk factors, leading to delayed diagnosis and treatment.

## Linked entities

- **Diseases:** lung adenocarcinoma (MONDO:0005061)

## Full-text entities

- **Genes:** MPO (myeloperoxidase) [NCBI Gene 4353], PRTN3 (proteinase 3) [NCBI Gene 5657] {aka ACPA, AGP7, C-ANCA, CANCA, MBN, MBT}, mucin [NCBI Gene 100508689]
- **Diseases:** IMA (MESH:D002288), coagulation (MESH:D001778), infection (MESH:D007239), COVID-19 (MESH:D000086382), cough (MESH:D003371), neutrophilia (MESH:C563010), HIV (MESH:D015658), fungal (MESH:D009181), Aspergillus (MESH:D001228), necrotic (MESH:D009336), Mycobacterium avium complex (MESH:D015270), infectious (MESH:D003141), cysts (MESH:D003560), organizing pneumonia (MESH:D000092124), infective endocarditis (MESH:D004696), tuberculosis (MESH:D014376), dyspnea (MESH:D004417), Cavitary Lung Disease (MESH:D008171), malignancy (MESH:D009369), adenocarcinoma (MESH:D000230), emphysema (MESH:D004646), airspace disease (MESH:D004194), abscesses (MESH:D000038), inflammation (MESH:D007249), bronchial obstruction (MESH:D002283), fever (MESH:D005334), septic emboli (MESH:D020766), pulmonary embolism (MESH:D011655), squamous cell carcinomas (MESH:D002294), hypoxia (MESH:D000860), bronchioloalveolar carcinoma (MESH:D002282), Cavitary (MESH:C566924), cavitating lesions (MESH:D009059), autoimmune (MESH:D001327), infiltrates (MESH:D017254), Mucinous adenocarcinoma of the lung (MESH:D000077192), pneumonia (MESH:D011014)
- **Chemicals:** piperacillin-tazobactam (MESH:D000077725), FDG (MESH:D019788), fluticasone (MESH:D000068298), amoxicillin-clavulanate (MESH:D019980), azithromycin (MESH:D017963), oxygen (MESH:D010100), vancomycin (MESH:D014640), levofloxacin (MESH:D064704)
- **Species:** Bacteria Latreille et al. 1825 (Bacteria stick insect, genus) [taxon 629395], Homo sapiens (human, species) [taxon 9606], Blastomyces (genus) [taxon 229219], Cryptococcus (genus) [taxon 79213], Coccidioides (genus) [taxon 5500], Histoplasma (genus) [taxon 5036]

## Full text

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## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12939229/full.md

## References

22 references — full list in the complete paper: https://tomesphere.com/paper/PMC12939229/full.md

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Source: https://tomesphere.com/paper/PMC12939229