# Do DNA Repair Gene Mutations Cause Clonal Hematopoiesis?

**Authors:** Dik C. van Gent, Zofia M. Komar

PMC · DOI: 10.3390/cancers18040691 · Cancers · 2026-02-20

## Full-text entities

- **Genes:** CHEK2 (checkpoint kinase 2) [NCBI Gene 11200] {aka CDS1, CHK2, HuCds1, LFS2, PP1425, RAD53}, TP53 (tumor protein p53) [NCBI Gene 7157] {aka BCC7, BMFS5, LFS1, P53, TRP53}, ATR (ATR checkpoint kinase) [NCBI Gene 545] {aka FCTCS, FRP1, MEC1, SCKL, SCKL1}, DNMT3A (DNA methyltransferase 3 alpha) [NCBI Gene 1788] {aka DNMT3A2, HESJAS, M.HsaIIIA, TBRS}, COL11A2 (collagen type XI alpha 2 chain) [NCBI Gene 1302] {aka DFNA13, DFNB53, FBCG2, HKE5, OSMEDA, OSMEDB}, ATM (ATM serine/threonine kinase) [NCBI Gene 472] {aka AT1, ATA, ATC, ATD, ATDC, ATE}, PALB2 (partner and localizer of BRCA2) [NCBI Gene 79728] {aka BROVCA5, FANCN, PNCA3}, BRCA1 (BRCA1 DNA repair associated) [NCBI Gene 672] {aka BRCAI, BRCC1, BROVCA1, FANCS, IRIS, PNCA4}, BRCA2 (BRCA2 DNA repair associated) [NCBI Gene 675] {aka BRCC2, BROVCA2, FACD, FAD, FAD1, FANCD}
- **Diseases:** myelodysplastic syndrome (MESH:D009190), hematologic aberrations (MESH:D019337), cancer (MESH:D009369), homologous (MESH:D006086), CH (MESH:C536227), injury to (MESH:D014947), prostate cancer (MESH:D011471), hereditary cancer (MESH:D009386), pancreatic cancer (MESH:D010190), breast cancer (MESH:D001943), breast, ovarian, prostate or pancreas cancer (MESH:D010051), cytotoxic (MESH:D064420), breast and ovarian cancer (MESH:D061325), leukemia (MESH:D007938)
- **Chemicals:** curcumin (MESH:D003474)
- **Species:** Homo sapiens (human, species) [taxon 9606]

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## References

7 references — full list in the complete paper: https://tomesphere.com/paper/PMC12939191/full.md

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Source: https://tomesphere.com/paper/PMC12939191