# ‘Molecular and Cellular Neuroscience’: Impacts of Eight Highly Cited Articles Published in This Section of Brain Sciences in 2024

**Authors:** Swapan K. Ray

PMC · DOI: 10.3390/brainsci16020188 · Brain Sciences · 2026-02-04

## TL;DR

This paper highlights eight influential neuroscience studies from 2024 that advanced understanding of neurological disorders and potential treatments.

## Contribution

The paper identifies and summarizes eight highly cited articles that contributed novel insights into molecular and cellular mechanisms of neurological diseases.

## Key findings

- The selected articles addressed diverse neurological conditions like Alzheimer’s disease and Rett syndrome.
- Several studies proposed experimental therapeutic strategies with translational potential.
- The work reflects significant progress in understanding molecular and cellular mechanisms of neurological disorders.

## Abstract

This year, the selection criteria for highly cited articles in the ‘Molecular and Cellular Neuroscience’ section of Brain Sciences were focused on publications that achieved a citation count of 10 or more during 2024. Applying this metric, the Editorial Office, in collaboration with myself as Associate Editor of the ‘Molecular and Cellular Neuroscience’ section of the journal, identified eight articles that not only exemplified the mission of this section but also made significant scientific contributions by advancing our current understanding of the molecular and cellular mechanisms underlying major and rare neurological disorders. These articles encompass miscellaneous topics, including Alzheimer’s disease (AD), chronic alcoholism, glioblastoma multiforme (GBM), amyotrophic lateral sclerosis (ALS), cognitive impairment, cerebrovascular disease, and Rett syndrome (RTT). Importantly, several contributions highlight experimental therapeutic strategies aimed at mitigating pathogenic mechanisms, offering promising avenues for translational research and future clinical applications.

## Linked entities

- **Diseases:** Alzheimer’s disease (MONDO:0004975), glioblastoma multiforme (MONDO:0018177), amyotrophic lateral sclerosis (MONDO:0004976), cerebrovascular disease (MONDO:0011057), Rett syndrome (MONDO:0010726)

## Full-text entities

- **Genes:** NFE2L2 (NFE2 like bZIP transcription factor 2) [NCBI Gene 4780] {aka IMDDHH, NRF2, Nrf-2}, SLC16A7 (solute carrier family 16 member 7) [NCBI Gene 9194] {aka MCT2}, PRRT2 (proline rich transmembrane protein 2) [NCBI Gene 112476] {aka BFIC2, BFIS2, DSPB3, DYT10, EKD1, FICCA}, APP (amyloid beta precursor protein) [NCBI Gene 351] {aka AAA, ABETA, ABPP, AD1, APPI, CTFgamma}, AKT1 (AKT serine/threonine kinase 1) [NCBI Gene 207] {aka AKT, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA}, KEAP1 (kelch like ECH associated protein 1) [NCBI Gene 9817] {aka INrf2, KLHL19}, PTK2B (protein tyrosine kinase 2 beta) [NCBI Gene 2185] {aka CADTK, CAKB, FADK2, FAK2, PKB, PTK}, BDNF (brain derived neurotrophic factor) [NCBI Gene 627] {aka ANON2, BULN2}, NTRK2 (neurotrophic receptor tyrosine kinase 2) [NCBI Gene 4915] {aka DEE58, EIEE58, GP145-TrkB, OBHD, TRKB, trk-B}, MECP2 (methyl-CpG binding protein 2) [NCBI Gene 4204] {aka AUTSX3, MRX16, MRX79, MRXS13, MRXSL, PPMX}, PIK3CB (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta) [NCBI Gene 5291] {aka P110BETA, PI3K, PI3KBETA, PIK3C1}
- **Diseases:** cerebrovascular disease (MESH:D002561), insulin resistance (MESH:D007333), neuroinflammation (MESH:D000090862), neurotoxic (MESH:D020258), AD (MESH:D000544), Cancer (MESH:D009369), chronic alcoholism (MESH:D006519), traumatic CNS injuries (MESH:D020196), RTT (MESH:D015518), mitochondrial damage (MESH:D028361), addictive behaviors (MESH:D000437), PD (MESH:D010300), inflammation (MESH:D007249), neurodevelopmental condition (MESH:D020763), Lactate-Infusion (MESH:D007775), injury (MESH:D014947), Neurodegenerative and Vascular Diseases (MESH:D019636), hyperglycemia (MESH:D006943), ALS (MESH:D000690), astrocytosis (MESH:D005911), GBM (MESH:D005909), nervous system (MESH:D009422), cognitive decline (MESH:D003072), hypoxia (MESH:D000860), brain tumor (MESH:D001932), cardiovascular abnormalities (MESH:D018376), MS (MESH:D009103), neurological disorders (MESH:D009461), Neuroglial Dysfunctions (MESH:D006331), amyloid (MESH:C000718787), T2D (MESH:D003924), motor neuron degeneration (MESH:D009410), Obesity (MESH:D009765), neurological diseases and injuries (MESH:D020271)
- **Chemicals:** DIM (MESH:C016392), Lactate (MESH:D019344), Ca2+ (-), I3C (MESH:C016517), tryptophan (MESH:D014364), kynurenine (MESH:D007737), Alcohol (MESH:D000438), lipid (MESH:D008055)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## References

32 references — full list in the complete paper: https://tomesphere.com/paper/PMC12939123/full.md

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Source: https://tomesphere.com/paper/PMC12939123