# Editorial for the Special Issue “Targeting Tumor Microenvironment for Cancer Therapy, 3rd Edition”

**Authors:** Cheng-Che Lee, Ming-Wei Lin

PMC · DOI: 10.3390/cimb48020155 · Current Issues in Molecular Biology · 2026-01-30

## Full-text entities

- **Genes:** CTNNB1 (catenin beta 1) [NCBI Gene 1499] {aka CTNNB, EVR7, MRD19, NEDSDV, armadillo}, KRAS (KRAS proto-oncogene, GTPase) [NCBI Gene 3845] {aka 'C-K-RAS, C-K-RAS, CFC2, K-RAS2A, K-RAS2B, K-RAS4A}, NFE2L2 (NFE2 like bZIP transcription factor 2) [NCBI Gene 4780] {aka IMDDHH, NRF2, Nrf-2}, HIF1A (hypoxia inducible factor 1 subunit alpha) [NCBI Gene 3091] {aka HIF-1-alpha, HIF-1A, HIF-1alpha, HIF1, HIF1-ALPHA, MOP1}, HSPA5 (heat shock protein family A (Hsp70) member 5) [NCBI Gene 3309] {aka BIP, GRP78, HEL-S-89n}, EPCAM (epithelial cell adhesion molecule) [NCBI Gene 4072] {aka Ber-Ep4, BerEp4, DIAR5, EGP-2, EGP314, EGP40}, EGFR (epidermal growth factor receptor) [NCBI Gene 1956] {aka ERBB, ERBB1, ERRP, HER1, NISBD2, NNCIS}, CD274 (CD274 molecule) [NCBI Gene 29126] {aka ADMIO5, B7-H, B7H1, PD-L1, PDCD1L1, PDCD1LG1}, CASP3 (caspase 3) [NCBI Gene 836] {aka CPP32, CPP32B, SCA-1}
- **Diseases:** toxicity (MESH:D064420), metastasis (MESH:D009362), Cancer (MESH:D009369), injury to (MESH:D014947), hypoxia (MESH:D000860), non-small cell lung cancer (MESH:D002289), hypoxic (MESH:D002534), gastric cancer (MESH:D013274), oral cancer (MESH:D009062)
- **Chemicals:** omega-3 polyunsaturated fatty acid linolenic acid (-), flavonoid (MESH:D005419), LA (MESH:D017962), ISL (MESH:C040920)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

_Full body text omitted from this summary view._ Fetch the complete paper as Markdown: https://tomesphere.com/paper/PMC12938889/full.md

## References

10 references — full list in the complete paper: https://tomesphere.com/paper/PMC12938889/full.md

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Source: https://tomesphere.com/paper/PMC12938889