# Transcatheter Aortic Valve Replacement for Severe Native Aortic Valve Regurgitation: A Multicenter and International Registry

## TL;DR

This study evaluates the effectiveness of transcatheter aortic valve replacement for severe aortic valve regurgitation across multiple centers and finds that while feasible, improvements are needed.

## Contribution

The study provides insights into the technical success and outcomes of transcatheter valve replacement for native aortic regurgitation using an international registry.

## Key findings

- Transcatheter aortic valve replacement for native aortic valve regurgitation has a technical success rate of 79.8%.
- Balloon-expandable valves are associated with fewer 30-day major adverse cardiac events in high-risk patients compared to self-expanding valves.
- Long-term outcomes are more influenced by patient risk factors than the type of valve used.

## Abstract

•Transcatheter aortic valve replacement for native aortic valve regurgitation is feasible but with modest technical success (79.8%).•Balloon-expandable valve use is linked to lower 30-day major adverse cardiac events versus self-expanding valve in high-risk patients.•Long-term outcomes driven by patient risk, not valve type.•Dedicated native aortic regurgitation systems still needed to improve procedural safety.

Transcatheter aortic valve replacement for native aortic valve regurgitation is feasible but with modest technical success (79.8%).

Balloon-expandable valve use is linked to lower 30-day major adverse cardiac events versus self-expanding valve in high-risk patients.

Long-term outcomes driven by patient risk, not valve type.

Dedicated native aortic regurgitation systems still needed to improve procedural safety.