# AGE-RAGE Axis Involvement in Allergies and Autoimmunity: Cellular Signaling, Barrier Dysfunction and Immune Polarization

## TL;DR

This paper explores how the AGE-RAGE pathway contributes to allergies and autoimmune diseases, highlighting its role in inflammation and potential for new treatments.

## Contribution

The paper systematically reviews the AGE-RAGE axis's involvement in multiple allergic and autoimmune conditions, emphasizing its dual role in immune polarization and barrier dysfunction.

## Key findings

- AGE-RAGE signaling contributes to pro-inflammatory responses in allergies and autoimmunity.
- The AGE-RAGE axis is implicated in diseases like asthma, atopic dermatitis, and rheumatoid arthritis.
- Targeting the AGE-RAGE pathway offers potential for new diagnostics and therapies.

## Abstract

Advanced glycation end-products (AGEs) are a variety of endogenous and exogenous substances that play an important role in inflammation, allergies, and autoimmune diseases. AGEs’ pathogenicity, alongside advanced oxidation protein products (AOPPs) and other ligands, lies in their ability to bind the receptor for advanced glycation end-products (RAGE) and trigger pro-inflammatory signaling pathways and cytokine release. The literature reports numerous studies on the role of the AGE-RAGE axis in various allergic conditions, including bronchial asthma, atopic dermatitis, food allergies, and autoimmune diseases such as rheumatoid arthritis, systemic lupus erythematosus, or Hashimoto’s thyroiditis, where the significant role of the AGE–RAGE axis in the immunopathogenesis of both allergic and autoimmune conditions is largely discussed and demonstrated. They suggest promising opportunities for the development of new diagnostic markers and targeted therapeutic strategies. However, further large-scale studies are needed to fully understand this multifaceted pathway and translate these insights into effective clinical interventions.