# Development of a Flexible Microneedle Array Electrode with a High Signal-to-Noise Ratio for Surface Bioelectrical Signal Recording

**Authors:** Bo Jiang, Ye Wang, Ruiqing Li, Yan Zhou, Lihua Ma, Dingjie Suo, Guangying Pei

PMC · DOI: 10.3390/bios16020108 · Biosensors · 2026-02-07

## TL;DR

This paper introduces a new flexible microneedle electrode that improves signal quality and comfort for long-term bioelectrical signal recording.

## Contribution

A novel flexible microneedle array electrode with high signal-to-noise ratio and minimal motion artifacts is developed using 316L stainless steel.

## Key findings

- The MNA electrode contact impedance is comparable to standard gold cup electrodes.
- The electrode shows high flexibility and strength with minimal motion artifacts during signal recording.
- The fabrication process enables efficient production for broader applications.

## Abstract

Microneedle array (MNA) electrodes have garnered significant attention for their capacity to record high-fidelity surface bioelectrical signals over extended periods and convenience. However, accuracy limitations in 3D-printed metal MNA electrodes, particularly concerning surface roughness and insufficient tip sharpness, have been reported. Additionally, the prevalent use of nonporous metal substrates often results in poor flexibility. This study proposes a novel MNA electrode featuring a lightweight flexible substrate and sharp, smooth microneedles. Utilizing micron-level metal 3D printing with 316L stainless steel, we fabricated the electrodes in a single step. We evaluated the MNA electrode-skin interface impedance via frequency sweep and assessed mechanical properties using porcine skin, followed by the collection and analysis of bioelectrical signals. The results demonstrate that the contact impedance of the MNA electrode is comparable to that of standard gold cup electrodes, with validated flexibility and strength. Furthermore, the MNA electrodes achieved a high signal-to-noise ratio and minimal motion artifacts during recording, thereby enhancing both comfort and signal quality. The efficient production process facilitates the broader application of metal MNA electrodes.

## Full-text entities

- **Diseases:** fracture (MESH:D050723), pain (MESH:D010146), inflammation (MESH:D007249), injury to (MESH:D014947)
- **Chemicals:** silver (MESH:D012834), copper (MESH:D003300), lithium (MESH:D008094), water (MESH:D014867), Methylene blue (MESH:D008751), polymers (MESH:D011108), stainless steel (MESH:D013193), oxygen (MESH:D010100), nickel-titanium (MESH:C013616), metal (MESH:D008670), gold (MESH:D006046), Parylene (MESH:C011055), formalin (MESH:D005557), argon (MESH:D001128), alcohol (MESH:D000438), p-xylene (MESH:C031286), polydimethylsiloxane (MESH:C013830), acetone (MESH:D000096), titanium (MESH:D014025), Silicon (MESH:D012825), MNA (-)
- **Species:** Sus scrofa (pig, species) [taxon 9823], Homo sapiens (human, species) [taxon 9606]
- **Mutations:** E4990A

## Full text

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## Figures

7 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12938060/full.md

## References

46 references — full list in the complete paper: https://tomesphere.com/paper/PMC12938060/full.md

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Source: https://tomesphere.com/paper/PMC12938060