# Intraoperative Fat Embolism Syndrome Causing Acute Right Ventricular Failure Successfully Treated With Veno-Arterial Extracorporeal Membrane Oxygenation: A Case Report

**Authors:** Shogo Mabuchi, Ikuko Miyawaki

PMC · DOI: 10.7759/cureus.102383 · Cureus · 2026-01-27

## TL;DR

A patient developed life-threatening complications during hip surgery, which were successfully treated with a specialized heart-lung support system.

## Contribution

First reported use of V-A ECMO for intraoperative fat embolism syndrome during elective arthroplasty.

## Key findings

- FES during hip surgery caused acute right ventricular failure and pulmonary hypertension.
- V-A ECMO provided effective circulatory support and enabled recovery without major complications.
- Early recognition and timely ECMO initiation may be lifesaving in such cases.

## Abstract

Fat embolism syndrome (FES) is a rare but potentially fatal complication of orthopedic surgery. Although extracorporeal support has been reported in trauma-related FES, the use of veno-arterial extracorporeal membrane oxygenation (V-A ECMO) for FES during elective arthroplasty has not been described. We report a case of a 67-year-old woman undergoing revision total hip arthroplasty. During the procedure, she developed profound hypoxemia and refractory hypotension following an iatrogenic femoral fracture prior to cement fixation. Despite fluid resuscitation and vasopressor and inotropic therapy, cardiovascular collapse progressed. The clinical course was consistent with FES complicated by acute right ventricular failure and pulmonary hypertension, and V-A ECMO was initiated for circulatory support. The patient was successfully liberated from ECMO on postoperative day 4 and discharged home without major complications. This case illustrates that fulminant intraoperative FES can cause abrupt right ventricular failure even during elective arthroplasty and suggests that early recognition and timely initiation of V-A ECMO may be lifesaving.

## Linked entities

- **Diseases:** hypotension (MONDO:0005468), pulmonary hypertension (MONDO:0005149)

## Full-text entities

- **Genes:** TNF (tumor necrosis factor) [NCBI Gene 7124] {aka DIF, IMD127, TNF-alpha, TNFA, TNFSF2, TNLG1F}, IL6 (interleukin 6) [NCBI Gene 3569] {aka BSF-2, BSF2, CDF, HGF, HSF, IFN-beta-2}
- **Diseases:** circulatory collapse (MESH:D012769), injury (MESH:D014947), inflammatory (MESH:D007249), ventricular overload (MESH:D019190), fracture (MESH:D050723), RV failure (MESH:D051437), cardiogenic shock (MESH:D012770), right bundle branch block (MESH:D002037), cardiopulmonary collapse (MESH:D006323), pulmonary edema (MESH:D011654), rash (MESH:D005076), right ventricular (RV) dilatation (MESH:C566255), respiratory failure (MESH:D012131), hypoxic (MESH:D002534), hemorrhage (MESH:D006470), pulmonary infiltrates (MESH:D017254), long-bone trauma (MESH:D050398), right heart strain (MESH:D013180), hypotension (MESH:D007022), FES (MESH:D004620), neurological abnormality (MESH:D009461), seizures (MESH:D012640), cor pulmonale (MESH:D011660), ARDS (MESH:D012128), pulmonary embolism (MESH:D011655), hypoxemia (MESH:D000860), thrombosis (MESH:D013927), subarachnoid hemorrhage (MESH:D013345), infection (MESH:D007239), cardiovascular collapse (MESH:D002318), bone cement (MESH:C563017), embolic (MESH:D004617), aspiration pneumonia (MESH:D011015), peripheral nerve block (MESH:D010523), hydrocephalus (MESH:D006849), neurological impairment (MESH:D009422), pulmonary hypertension (MESH:D006976), femoral fracture (MESH:D005264)
- **Chemicals:** oxygen (MESH:D010100), phenylephrine (MESH:D010656), adrenaline (MESH:D004837), noradrenaline (MESH:D009638), CKRT (-), dobutamine (MESH:D004280)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12937950/full.md

## References

20 references — full list in the complete paper: https://tomesphere.com/paper/PMC12937950/full.md

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Source: https://tomesphere.com/paper/PMC12937950