# Single-Cone vs. Carrier-Based Root Canal Obturation with a Calcium-Silicate-Based Sealer: An In Vitro µ-CT Analysis

**Authors:** Vincenzo Tosco, Riccardo Monterubbianesi, Michele Furlani, Andrea Spinelli, Fausto Zamparini, Giovanna Orsini

PMC · DOI: 10.3390/biomimetics11020152 · Biomimetics · 2026-02-19

## TL;DR

This study compares two root canal filling methods using a calcium-silicate sealer, finding that the carrier-based method results in fewer gaps and better filling quality.

## Contribution

The study provides empirical evidence comparing single-cone and carrier-based obturation with a calcium-silicate-based sealer using µ-CT analysis.

## Key findings

- Carrier-based obturation resulted in significantly fewer voids and smaller total void volume compared to the single-cone technique.
- Single-cone technique showed larger voids mainly in the coronal and middle thirds of the root canal.
- Both techniques provided a reliable apical seal.

## Abstract

The introduction of calcium-silicate-based sealers has renewed interest in simplified obturation protocols such as the single-cone technique, although warm techniques, including carrier-based obturation, are still considered the gold standard. The aim of this in vitro study was to compare the quality of root canal obturation achieved with single-cone and carrier-based techniques when used with the same calcium-silicate-based sealer. Thirty extracted mandibular molars were prepared using a standardized rotary instrumentation protocol and randomly assigned to two groups (n = 15 each): Group A was obturated using a carrier-based technique (Soft-Core obturators), while Group B was obturated with the single-cone technique. All canals were filled with the same calcium-silicate-based sealer (NeoSEALER Flo). Micro–computed tomography was used to evaluate the number and volume of voids of the obturation. Quantitative analysis showed that Group A exhibited a significantly lower number of voids (9.0 ± 5.0) and reduced total void volume (2.58 ± 0.8 mm3) compared with Group B (22.0 ± 10.1 voids; 4.71 ± 1.1 mm3; p = 0.00002 and p = 0.0026, respectively). Qualitative analysis confirmed that carrier-based obturation achieved a denser and more homogeneous filling, while the single-cone technique showed larger voids mainly in the coronal and middle thirds. Both techniques provided a reliable apical seal. Within the limitations of this in vitro study, carrier-based obturation demonstrated superior overall filling quality compared with the single-cone technique when used with a calcium-silicate-based sealer, particularly in the middle and coronal regions of the root canal.

## Full-text entities

- **Genes:** CMAS (cytidine monophosphate N-acetylneuraminic acid synthetase) [NCBI Gene 55907] {aka CSS}
- **Diseases:** infection (MESH:D007239), caries (MESH:D003731), periapical lesions (MESH:D010483), root resorption (MESH:D012391), calcifications (MESH:D002114), injury to (MESH:D014947), fractures (MESH:D050723)
- **Chemicals:** calcium (MESH:D002118), sodium hypochlorite (MESH:D012973), Calibrated gutta-percha (-), aluminum (MESH:D000535), calcium aluminate (MESH:C035219), apatite (MESH:D001031), EDTA (MESH:D004492), chloramine (MESH:C030816), Calcium-Silicate (MESH:C031293)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

6 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12937792/full.md

## References

42 references — full list in the complete paper: https://tomesphere.com/paper/PMC12937792/full.md

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Source: https://tomesphere.com/paper/PMC12937792