# Electrochemical Sensors as a Tool for Taste Perception in Pharmaceutical Products: Advances and Perspectives

**Authors:** Juliana Luz Melo Gongoni, Marilia Medeiros, Hatylas Azevedo, Margarete Moreno de Araújo

PMC · DOI: 10.3390/bios16020084 · Biosensors · 2026-01-30

## TL;DR

This paper reviews electronic tongue technology as a tool for evaluating taste in pharmaceuticals, offering an objective alternative to human taste panels.

## Contribution

The paper provides a comprehensive review of e-tongue systems and their potential to complement traditional methods in pharmaceutical taste evaluation.

## Key findings

- E-tongue systems can objectively mimic human taste perception for pharmaceutical applications.
- E-tongue data processing methods are improving, enabling better formulation development.
- E-tongue technology can accelerate drug development and improve patient adherence.

## Abstract

Taste masking in pharmaceutical products is a complex and subjective process that requires reliable evaluation methods. This review focuses on the electronic tongue (e-tongue), an emerging sensor-based technology designed to mimic human taste perception without the need for human panels. E-tongue systems provide objective data to support the development of palatable formulations. In this review, we discuss the principles, types of e-tongue devices, data processing approaches, and their applications in pharmaceutical research. By comparing e-tongue performance with human taste assessment, we highlight its potential as a complementary tool to traditional in vitro assays, accelerating formulation development and improving patient adherence.

## Full-text entities

- **Genes:** SLC5A1 (solute carrier family 5 member 1) [NCBI Gene 6523] {aka D22S675, NAGT, SGLT-1, SGLT1}
- **Diseases:** bitter (MESH:D013651), injury to (MESH:D014947), gastric parietal tumor (MESH:D013274), fatigue (MESH:D005221), dysphagia (MESH:D003680)
- **Chemicals:** eucalyptus oil (MESH:D000078122), gold (MESH:D006046), Nizatidine (MESH:D016567), brivaracetam (MESH:C482793), ibuprofen (MESH:D007052), sucralose (MESH:C026285), oleyl amine (MESH:C008703), acetaminophen (MESH:D000082), gallic acid (MESH:D005707), sugar (MESH:D000073893), chitosan (MESH:D048271), salt (MESH:D012492), DA (MESH:C025953), beta-cyclodextrin (MESH:C031215), Dowex-50 (MESH:C077982), menthol (MESH:D008610), carbon (MESH:D002244), alanine (MESH:D000409), polymer (MESH:D011108), trioctyl trimellitate (MESH:C034367), Eudragit E (MESH:C102808), clindamycin (MESH:D002981), water (MESH:D014867), AgCl (MESH:C037548), bis (2-ethylhexyl) sebacate (MESH:C037634), iron oxide (MESH:C000499), Ag (MESH:D012834), oxytetracycline (MESH:D010118), borneol (MESH:C022871), decyl alcohol (MESH:C029383), PAH (MESH:D011084), cyclophosphamide (MESH:D003520), xanthan gum (MESH:C002563), Ethanol (MESH:D000431), cholesterol (MESH:D002784), beta-cyclodextrins (MESH:D047392), prednisolone (MESH:D011239), ODT-101 (-), graphene (MESH:D006108), dioctyl phosphate (MESH:C063695), 2-nitrophenyl octyl ether (MESH:C519952), olive oils (MESH:D000069463), silica (MESH:D012822), dioctyl phenylphosphonate (MESH:C102801), fenchone (MESH:C027327), sulfanilamide (MESH:D000077145), Amberlite IRP-69 (MESH:C406464), DOP (MESH:D015103), amino acids (MESH:D000596), CDs (MESH:D003505), PVC (MESH:D011143), oil (MESH:D009821), carbohydrates (MESH:D002241), 1-hexadecanol (MESH:C005031), mannitol (MESH:D008353), taurine (MESH:D013654), lipid (MESH:D008055), neotame (MESH:C404525), OA (MESH:D019319), MOS (MESH:D008982)
- **Species:** Theobroma cacao (cacao, species) [taxon 3641], Canis lupus familiaris (dog, subspecies) [taxon 9615], Solanum lycopersicum (tomato, species) [taxon 4081], Rattus norvegicus (brown rat, species) [taxon 10116], Homo sapiens (human, species) [taxon 9606], Rodentia (rodent, order) [taxon 9989]
- **Cell lines:** HGT-1 — Homo sapiens (Human), Gastric adenocarcinoma, Cancer cell line (CVCL_A609), CHO — Cricetulus griseus (Chinese hamster), Spontaneously immortalized cell line (CVCL_0213)

## Full text

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## Figures

11 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12937762/full.md

## References

176 references — full list in the complete paper: https://tomesphere.com/paper/PMC12937762/full.md

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Source: https://tomesphere.com/paper/PMC12937762