# Real-World Experience in the Treatment of Biofilm-Associated Wounds Using Medical-Grade Honey: A Retrospective Case Series

## TL;DR

Medical-grade honey helped heal most biofilm-related wounds in a small study, showing promise as an alternative treatment.

## Contribution

Demonstrates clinical effectiveness of medical-grade honey in treating biofilm-associated wounds in real-world settings.

## Key findings

- Eight out of ten biofilm-associated wounds achieved complete healing with medical-grade honey.
- Most wounds showed reduced exudate and inflammation, along with tissue regeneration.
- Two wounds did not fully heal, suggesting variability in treatment response.

## Abstract

Background/Objectives: Wounds complicated by biofilm formation remain a major challenge in wound management. Medical-grade honey (MGH) possesses potent antimicrobial and biofilm-disrupting properties. This study aimed to evaluate the clinical effectiveness of MGH in the treatment of biofilm-associated wounds. Methods: A retrospective case series was conducted involving ten patients with biofilm-suspected wounds treated at Kaohsiung Medical University Hospital and Wesing Hospital. All wounds exhibited positive bacterial cultures and clinical signs of biofilm formation. MGH was applied topically, and wound progression was monitored throughout the treatment period. Results: Eight out of ten wounds achieved complete healing, with a median healing time of 16 weeks (range: 4–46 weeks). Most wounds demonstrated reduced exudate and inflammation, along with progressive granulation and epithelialization. Two wounds did not fully heal within the follow-up period. Conclusions: MGH appears to be a promising adjunctive therapy for wounds associated with biofilm formation, particularly in cases refractory to conventional antibiotic therapy. Further large-scale, controlled studies are warranted to confirm these preliminary findings.