# Complete Remission After Percutaneous Renal Artery Angioplasty for Focal Segmental Glomerulosclerosis due to Takayasu Disease: A Case Report

## TL;DR

A young woman with Takayasu disease showed complete remission of kidney issues after a procedure to widen a narrowed renal artery.

## Contribution

This case report demonstrates that percutaneous renal angioplasty can lead to remission in focal segmental glomerulosclerosis linked to Takayasu disease.

## Key findings

- PTRA led to a decrease in urine protein levels and remission in a patient with Takayasu disease and focal segmental glomerulosclerosis.
- Renal artery stenosis in Takayasu disease may cause focal segmental glomerulosclerosis through increased intraglomerular pressure.
- Early PTRA intervention is suggested to be effective when renal dysfunction is mild.

## Abstract

Renal artery stenosis is a common complication of Takayasu disease; however, the presence of nephrotic syndrome is rare. Percutaneous transluminal renal angioplasty (PTRA) is performed for renal artery stenosis; however, its efficacy is unclear for renal artery stenosis complicated with nephrotic syndrome. This is a case report of Takayasu disease in an 18-year-old woman with no relevant medical history. Magnetic resonance angiography revealed bilateral renal artery stenosis, and nephrotic syndrome was noted. Focal segmental glomerulosclerosis was diagnosed based on renal biopsy. As atrophy was observed in the right kidney, PTRA was performed for the left renal artery stenosis. Urine protein levels decreased subsequently, leading to remission. Renal artery stenosis may commonly occur due to Takayasu disease; however, the resulting accentuation of the renin-angiotensin-aldosterone cascade and increased intraglomerular pressure may cause focal segmental glomerulosclerosis. PTRA may induce remission if renal dysfunction is mild, and it should be performed as early as possible.