# Reciprocal effects between loneliness and sleep disturbances from adolescence to mid-adulthood: the HUNT study

**Authors:** Nayan Parlikar, Joanna McHugh Power, Philip Hyland, Andrew N Coogan, Kirsti Kvaløy, Linn Beate Strand, Geir Arild Espnes, Steinar Krokstad, Unni Karin Moksnes

PMC · DOI: 10.1093/sleepadvances/zpag004 · Sleep Advances: A Journal of the Sleep Research Society · 2026-01-12

## TL;DR

This study explores how loneliness and sleep problems influence each other from adolescence to midlife, finding that sleep issues in early adulthood predict later loneliness.

## Contribution

The study reveals a bidirectional but asymmetric relationship between loneliness and sleep disturbances over time, with sleep problems in early adulthood predicting future loneliness.

## Key findings

- Sleep problems in early adulthood predict increased loneliness in midlife.
- Anxiety and depression mediate the longitudinal links between loneliness and sleep disturbances.
- Loneliness and sleep disturbances show high stability across development.

## Abstract

Loneliness and sleep disturbances are prevalent and interrelated public health concerns, especially during the transition from adolescence to adulthood, a period marked by major psychological and social changes. However, less is known about their potential reciprocal relationship across development. This study examines the longitudinal, bidirectional associations between loneliness and sleep from adolescence to mid-adulthood using data from the Trøndelag Health Study (HUNT).

We used data from Young-HUNT1 (1995–1997), HUNT3 (2006–2008), and HUNT4 (2017–2019), including 2185 participants (60.6% female). Loneliness and sleep were measured using harmonized items across waves. Structural equation modeling tested cross-lagged associations between loneliness and sleep, adjusting for sociodemographic and mental health covariates. Mediation analyses explored the underlying mechanisms of anxiety and depression.

Loneliness declined over time, while sleep showed a fluctuating pattern. Both constructs demonstrated high temporal stability. Loneliness did not significantly predict future sleep problems; however, sleep in early adulthood was a predictor of increased loneliness in midlife. Cross-sectional associations between loneliness and sleep were significant in adolescence and mid-adulthood. Mediation analyses showed that anxiety and depression mediated the longitudinal links between loneliness and sleep disturbances across different life stages.

Loneliness and sleep are stable and interrelated across development. Sleep problems in early adulthood appear to be a stronger predictor of future loneliness, highlighting sleep as a potential intervention target to reduce long-term social and mental health difficulties. Symptoms of anxiety and depression mediated these associations, indicating key psychological pathways linking loneliness and sleep over time.

## Full-text entities

- **Diseases:** sleep disruption (MESH:D019958), Anxiety (MESH:D001007), Insomnia (MESH:D007319), Sleep Disturbances (MESH:D012893), inflammation (MESH:D007249), difficulty (MESH:D051346), emotional dysregulation (MESH:D021081), mental distress (MESH:D012128), neuroendocrine dysregulation (MESH:D018358), difficulty falling asleep (MESH:C537863), health difficulties (OMIM:603663), mental (MESH:D008607), internalizing symptoms (MESH:D000082122), chronic (MESH:D002908), depressed (MESH:D003866)
- **Chemicals:** cortisol (MESH:D006854), alcohol (MESH:D000438)
- **Species:** Homo sapiens (human, species) [taxon 9606]
- **Cell lines:** HSCL-5 — Mus musculus (Mouse), Transformed cell line (CVCL_5U93)

## Full text

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## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12936869/full.md

## References

110 references — full list in the complete paper: https://tomesphere.com/paper/PMC12936869/full.md

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Source: https://tomesphere.com/paper/PMC12936869