# A case of delayed-onset postoperative pyoderma gangrenosum complicated with chronic myelomonocytic leukemia treated with systemic corticosteroids and spesolimab

**Authors:** Gong Zhenni, Tao Siqi, He Li, Ma Xiaoya, Jia Xuesong, Ci Hai, Wang Xue

PMC · DOI: 10.1016/j.jdcr.2025.11.053 · JAAD Case Reports · 2025-12-17

## Full-text entities

- **Genes:** CSF3R (colony stimulating factor 3 receptor) [NCBI Gene 1441] {aka CD114, GCSFR, SCN7}, SETBP1 (SET binding protein 1) [NCBI Gene 26040] {aka MRD29, SEB}, STAG2 (STAG2 cohesin complex component) [NCBI Gene 10735] {aka HPE13, MKMS, NEDXCF, SA-2, SA2, SCC3B}, NFKB1 (nuclear factor kappa B subunit 1) [NCBI Gene 4790] {aka CVID12, EBP-1, KBF1, NF-kB, NF-kB1, NF-kappa-B1}, CXCL8 (C-X-C motif chemokine ligand 8) [NCBI Gene 3576] {aka GCP-1, GCP1, IL8, LECT, LUCT, LYNAP}, IL1RL2 (interleukin 1 receptor like 2) [NCBI Gene 8808] {aka IL-1Rrp2, IL-36R, IL1R-rp2, IL1RRP2}, IL1B (interleukin 1 beta) [NCBI Gene 3553] {aka IL-1, IL1-BETA, IL1F2, IL1beta}, TET2 (tet methylcytosine dioxygenase 2) [NCBI Gene 54790] {aka IMD75, KIAA1546, MDS}, ASXL1 (ASXL transcriptional regulator 1) [NCBI Gene 171023] {aka BOPS, MDS}, CXCL1 (C-X-C motif chemokine ligand 1) [NCBI Gene 2919] {aka FSP, GRO1, GROa, MGSA, MGSA-a, NAP-3}, TNF (tumor necrosis factor) [NCBI Gene 7124] {aka DIF, IMD127, TNF-alpha, TNFA, TNFSF2, TNLG1F}, PHF6 (PHD finger protein 6) [NCBI Gene 84295] {aka BFLS, BORJ, CENP-31}, IL6 (interleukin 6) [NCBI Gene 3569] {aka BSF-2, BSF2, CDF, HGF, HSF, IFN-beta-2}
- **Diseases:** PG (MESH:D017511), CMML (MESH:D015477), systemic diseases (MESH:D034721), pustular psoriasis (MESH:D011565), necrosis (MESH:D009336), Fever (MESH:D005334), neutrophilic dermatosis (MESH:D016463), hyperplasia (MESH:D006965), hematologic malignancies (MESH:D019337), systemic (MESH:D015619), coronary atherosclerotic disease (MESH:D003324), myelofibrosis (MESH:D055728), necrotic ulcer (MESH:D014456), leukocytosis (MESH:D007964), clonal hematopoietic stem cell disorder (MESH:D000090267), cutaneous infection (MESH:D007239), cerebral infarction (MESH:D002544), myeloid tumor (MESH:D009369), ischemic (MESH:D002545), monocytosis (MESH:C538328), hypertension (MESH:D006973), inguinal hernia (MESH:D006552), pain (MESH:D010146), hyperpigmentation (MESH:D017495), hypopigmentation (MESH:D017496), skin lesions (MESH:D012871), abscess (MESH:D000038), inflammation (MESH:D007249), anemia (MESH:D000740), vasculitis (MESH:D014657)
- **Chemicals:** Eosin (MESH:D004801), ceftazidime (MESH:D002442), steroid (MESH:D013256), methylprednisolone (MESH:D008775), Spesolimab (MESH:C000712973), piperacillin-tazobactam (MESH:D000077725), ceftriaxone (MESH:D002443), Hematoxylin (MESH:D006416)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

_Full body text omitted from this summary view._ Fetch the complete paper as Markdown: https://tomesphere.com/paper/PMC12936781/full.md

## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12936781/full.md

## References

9 references — full list in the complete paper: https://tomesphere.com/paper/PMC12936781/full.md

---
Source: https://tomesphere.com/paper/PMC12936781