# Mid‐term performance of a unicompartmental knee prosthesis

**Authors:** Akbar Nawab, Patricia Bartelt, Ryan Molli, J. Mandume Kerina, Samuel Wellman, Dean Sukin, Stefano Biguzzi, Colleen Nawab, Daniel Hass, Ashton Dukes, Anthony Robins

PMC · DOI: 10.1002/jeo2.70670 · Journal of Experimental Orthopaedics · 2026-02-26

## TL;DR

This study shows that a unicompartmental knee prosthesis provides good long-term results with high survival rates and low complications.

## Contribution

The study provides new evidence supporting unicompartmental knee arthroplasty as a viable option with high survivorship and functional outcomes.

## Key findings

- Midterm patient-reported outcomes showed significant and sustained improvements through 5 years.
- Kaplan–Meier survivorship was 98.1% at 5 years with low revision rates.
- Radiolucencies did not significantly affect outcomes, and complications were rare.

## Abstract

The objective of this study was to report midterm patient‐reported outcomes (PROs) and survivorship of the Medacta MOTO Medial® Unicompartmental prosthesis (Medacta International, Castel San Petro, Switzerland) and surgical technique.

This prospective, multicentre study included 207 adults aged 43–85. Of these, 170 reached 2‐year and 90 reached 5‐year follow‐up. PROs included the forgotten joint score (FJS), Oxford knee score (OKS) and knee injury and osteoarthritis outcome score (KOOS) subscales: Pain, Symptoms, ADL, Sport and QOL. Stress radiographs were divided into three types, quantifying the amount of medial space opening and deformity correction. Data were collected at preoperative, intraoperative, 4 weeks, 6 months, 1‐year, 2‐year and 5‐year. Complications, revisions and Kaplan–Meier survivorship were analysed.

All PROs showed statistically significant improvements starting at 6 months and maintained through 5‐year. Pre‐operative standing full‐length x‐rays, averaged 6.5° varus. The average change in mechanical axis was less than 1° at 5‐year. No difference in PROs was found between patients with (N = 63) and without (N = 27) radiolucencies. Only two cases with radiolucencies progressed to revision. There was one superficial infection and four revisions to the total knee arthroplasty. No thromboembolic, instability or arthrofibrosis complications occurred. Kaplan–Meier survivorship was 98.5% at 2‐year and 98.1% at 5‐year.

Unicompartmental knee replacement with implant system that allows surgical flexibility and independent balancing is a surgical option with promise of excellent functional outcomes, low complication rates and high survivorship (98.1% at 5‐year). These results challenge previous studies indicating high revision rates and support the utilisation of unicompartmental arthroplasty for properly indicated patients.

Level II, prognostic studies.

## Linked entities

- **Diseases:** osteoarthritis (MONDO:0005178)

## Full-text entities

- **Genes:** CLEC4D (C-type lectin domain family 4 member D) [NCBI Gene 338339] {aka CD368, CLEC-6, CLEC6, CLECSF8, Dectin-3, MCL}, KL (klotho) [NCBI Gene 9365] {aka HFTC3, KLA}
- **Diseases:** arthritic (MESH:D015535), metabolic disorder (MESH:D008659), osteoarthritis (MESH:D010003), flexion contracture (MESH:D003286), knee disease (MESH:D000092443), knee pain (MESH:D046788), ACL rupture (MESH:D012421), loss of proprioception (MESH:D020886), postoperative pain (MESH:D010149), compartment failure (MESH:D051437), psychiatric illness (MESH:D001523), osteochondritis dissecans (MESH:D010008), swelling (MESH:D004487), anterior cruciate ligament (MESH:D000070598), medial condyle collapse (MESH:D000092524), hematoma (MESH:D006406), unicompartmental disease (MESH:D004194), complication (MESH:D008107), stitch abscess (MESH:D000038), Pain (MESH:D010146), instability (MESH:D043171), valgus (MESH:D060906), collateral ligament (MESH:D000082122), Orthopedics (MESH:D009140), allergy (MESH:D004342), thromboembolic complications (MESH:D013923), Infection (MESH:D007239), osteoporosis (MESH:D010024), Osteomalacia (MESH:D010018), laceration (MESH:D022125), DVT (MESH:D020246), medial knee osteoarthritis (MESH:D020370), FJS (MESH:D007592), medial compartment arthritis (MESH:D003161), PASS (MESH:D012816), MCID (MESH:D000076263), Knee arthritis (MESH:D001168), OKS (MESH:D007718), aseptic loosening (MESH:D011475), varus (MESH:D060905)
- **Chemicals:** polyethylene (MESH:D020959), tranexamic acid (MESH:D014148), Benadryl (MESH:D004155), Titanium (MESH:D014025), Moximed (-), Keflex (MESH:D002506), Cobalt-Chrome (MESH:D002858)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

11 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12936700/full.md

## References

51 references — full list in the complete paper: https://tomesphere.com/paper/PMC12936700/full.md

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Source: https://tomesphere.com/paper/PMC12936700