# Uncovering the role of genetic polymorphisms in cervical insufficiency

## TL;DR

This paper reviews the genetic factors and pathways involved in cervical insufficiency, a condition causing premature delivery.

## Contribution

The paper provides a comprehensive review of genes and pathways linked to cervical insufficiency's genetic basis.

## Key findings

- Genes related to collagen, inflammation, immune, and coagulative factors are implicated in cervical insufficiency.
- Current knowledge on genetic components and pathways of cervical insufficiency is summarized.
- Scientific gaps and future research directions are identified to better understand the condition's pathophysiology.

## Abstract

Cervical insufficiency (CI) is characterized by spontaneous dilation of the cervix in the absence of painful uterine contractions in the mid‐trimester, leading to premature delivery. It is responsible for up to 20% of second trimester pregnancy losses, mostly <24 weeks. This life‐threatening condition for the growing fetus faced during pregnancy is of complex etiology. The genetic background of this disorder is of fundamental importance. A number of genes have been implicated in CI, highlighting the role of collagen, inflammation, immune, and coagulative factors as key players in CI pathogenesis. This review sheds light on current knowledge regarding the genetic component of CI, analyzing the genes that have been associated with this pathology and describing already identified pathways that participate in CI pathogenesis. Current scientific gaps and future research directions are also discussed in an attempt to disentangle the mystery of CI pathophysiology.

Pathways and genes implicated in CI pathogenesis.