# The enigma of nuclear FMRP: facts and myths

**Authors:** Edouard W. Khandjian, Laetitia Davidovic

PMC · DOI: 10.3389/fcell.2026.1756661 · Frontiers in Cell and Developmental Biology · 2026-02-12

## Full-text entities

- **Genes:** EIF1 (eukaryotic translation initiation factor 1) [NCBI Gene 10209] {aka A121, EIF-1, EIF1A, ISO1, SUI1}, XPO1 (exportin 1) [NCBI Gene 7514] {aka CRM-1, CRM1, emb, exp1}, NES (nestin) [NCBI Gene 10763] {aka Nbla00170}, FMR1 (fragile X messenger ribonucleoprotein 1) [NCBI Gene 2332] {aka FMRP, FRAXA, POF, POF1}, NUFIP2 (nuclear FMR1 interacting protein 2) [NCBI Gene 57532] {aka 182-FIP, 82-FIP, FIP-82, NUFP2, PIG1}, MDC1 (mediator of DNA damage checkpoint 1) [NCBI Gene 9656] {aka NFBD1}
- **Diseases:** intellectual disability (MESH:D008607), autism spectrum disorder (MESH:D000067877), FXS (MESH:D005600)
- **Chemicals:** DAPI (MESH:C007293), LMB (MESH:C038753)
- **Species:** Homo sapiens (human, species) [taxon 9606], Rattus norvegicus (brown rat, species) [taxon 10116], Gallus gallus (bantam, species) [taxon 9031], Human immunodeficiency virus 1 (no rank) [taxon 11676]
- **Cell lines:** HeLa — Homo sapiens (Human), Human papillomavirus-related endocervical adenocarcinoma, Cancer cell line (CVCL_0030), HeLa S3 — Homo sapiens (Human), Human papillomavirus-related endocervical adenocarcinoma, Cancer cell line (CVCL_0058)

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## References

33 references — full list in the complete paper: https://tomesphere.com/paper/PMC12936046/full.md

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Source: https://tomesphere.com/paper/PMC12936046