# Editorial: Mechanisms and therapeutic opportunities of T-cell impairment in cancer immunity and immunotherapy

**Authors:** Guillaume Beyrend-Frizon

PMC · DOI: 10.3389/fimmu.2026.1795868 · Frontiers in Immunology · 2026-02-12

## Full-text entities

- **Genes:** MAP2K7 (mitogen-activated protein kinase kinase 7) [NCBI Gene 5609] {aka JNKK2, MAPKK7, MEK, MEK 7, MKK7, PRKMK7}, Lag3 (lymphocyte-activation gene 3) [NCBI Gene 16768] {aka CD223, LAG-3, Ly66}, DDX19A (DEAD-box helicase 19A) [NCBI Gene 55308] {aka DDX19-DDX19L, DDX19L}, SMAD3 (SMAD family member 3) [NCBI Gene 397260] {aka MADH3}, ICAM1 (intercellular adhesion molecule 1) [NCBI Gene 396750] {aka ICAM-1}, TP53 (tumor protein p53) [NCBI Gene 7157] {aka BCC7, BMFS5, LFS1, P53, TRP53}, TENM1 (teneurin transmembrane protein 1) [NCBI Gene 10178] {aka ODZ1, ODZ3, TEN-M1, TEN1, TNM, TNM1}, CD4 (CD4 molecule) [NCBI Gene 404704], TRBV20OR9-2 (T cell receptor beta variable 20/OR9-2 (non-functional)) [NCBI Gene 6962] {aka CDR3, TCRBV20S2, TCRBV2O, TCRBV2S2O}, LAMP1 (lysosome associated membrane protein 1) [NCBI Gene 3916] {aka CD107a, LAMPA, LGP120}, Cd4 (CD4 antigen) [NCBI Gene 12504] {aka L3T4, Ly-4}, MRPL10 (mitochondrial ribosomal protein L10) [NCBI Gene 124995] {aka L10MT, MRP-L10, MRP-L8, MRPL8, RPML8, uL10m}, SLC7A11 (solute carrier family 7 member 11) [NCBI Gene 23657] {aka CCBR1, xCT}, AKT1 (AKT serine/threonine kinase 1) [NCBI Gene 207] {aka AKT, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA}, TNFSF10 (TNF superfamily member 10) [NCBI Gene 8743] {aka APO2L, Apo-2L, CD253, TANCR, TL2, TNLG6A}, FASLG (Fas ligand) [NCBI Gene 356] {aka ALPS1B, APT1LG1, APTL, CD178, CD95-L, CD95L}, CD276 (CD276 molecule) [NCBI Gene 80381] {aka 4Ig-B7-H3, B7-H3, B7H3, B7RP-2}, HK1 (hexokinase 1) [NCBI Gene 3098] {aka CNSHA5, HK, HK1-ta, HK1-tb, HK1-tc, HKD}, CSF3 (colony stimulating factor 3) [NCBI Gene 1440] {aka C17orf33, CSF3OS, GCSF}, HPRT1 (hypoxanthine phosphoribosyltransferase 1) [NCBI Gene 3251] {aka HGPRT, HPRT}, HAVCR2 (hepatitis A virus cellular receptor 2) [NCBI Gene 84868] {aka CD366, HAVcr-2, KIM-3, SPTCL, TIM3, TIMD-3}, IL20RA (interleukin 20 receptor subunit alpha) [NCBI Gene 53832] {aka CRF2-8, IL-20R-alpha, IL-20R1, IL-20RA}, CSF1R (colony stimulating factor 1 receptor) [NCBI Gene 1436] {aka BANDDOS, C-FMS, CD115, CSF-1R, CSFR, FIM2}, CD4 (CD4 molecule) [NCBI Gene 920] {aka CD4mut, IMD79, Leu-3, OKT4D, T4}, IFNG (interferon gamma) [NCBI Gene 3458] {aka IFG, IFI, IMD69}, GZMB (granzyme B) [NCBI Gene 3002] {aka C11, CCPI, CGL-1, CGL1, CSP-B, CSPB}, NDFIP1 (Nedd4 family interacting protein 1) [NCBI Gene 80762] {aka N4WBP5}, CCR2 (C-C motif chemokine receptor 2) [NCBI Gene 729230] {aka CC-CKR-2, CCR-2, CCR2A, CCR2B, CD192, CKR2}, EFNB2 (ephrin B2) [NCBI Gene 1948] {aka EPLG5, HTKL, Htk-L, LERK5, ephrin-B2}, TWIST1 (twist family bHLH transcription factor 1) [NCBI Gene 7291] {aka ACS3, BPES2, BPES3, CRS, CRS1, CSO}, PCMT1 (protein-L-isoaspartate (D-aspartate) O-methyltransferase) [NCBI Gene 5110] {aka PIMT}, LAG3 (lymphocyte activating 3) [NCBI Gene 100125962] {aka CD223, LAG-3}, MTOR (mechanistic target of rapamycin kinase) [NCBI Gene 2475] {aka FRAP, FRAP1, FRAP2, RAFT1, RAPT1, SKS}, Cd276 (CD276 antigen) [NCBI Gene 102657] {aka 6030411F23Rik, B7-H3, B7RP-2, B7h3}, CTLA4 (cytotoxic T-lymphocyte associated protein 4) [NCBI Gene 1493] {aka ALPS5, CD, CD152, CELIAC3, CTLA-4, GRD4}, SLC2A3 (solute carrier family 2 member 3) [NCBI Gene 6515] {aka GLUT3}, TIGIT (T cell immunoreceptor with Ig and ITIM domains) [NCBI Gene 201633] {aka VSIG9, VSTM3, WUCAM}, BTG3 (BTG anti-proliferation factor 3) [NCBI Gene 10950] {aka ANA, ANA/BTG3, APRO4, TOB5, TOB55, TOFA}, KDM1A (lysine demethylase 1A) [NCBI Gene 100127157] {aka AOF2, KDM1, LSD1}, CD40 (CD40 molecule) [NCBI Gene 958] {aka Bp50, CDW40, TNFRSF5, p50}, CD8A (CD8 subunit alpha) [NCBI Gene 925] {aka CD8, CD8alpha, IMD116, Leu2, p32}, CD274 (CD274 molecule) [NCBI Gene 574058] {aka PDL1}, LAG3 (lymphocyte activating 3) [NCBI Gene 3902] {aka CD223}, TGFB1 (transforming growth factor beta 1) [NCBI Gene 7040] {aka CAEND1, CED, DPD1, IBDIMDE, LAP, TGF-beta1}, TREML2 (triggering receptor expressed on myeloid cells like 2) [NCBI Gene 79865] {aka C6orf76, TLT-2, TLT2, dJ238O23.1}, DNER (delta/notch like EGF repeat containing) [NCBI Gene 92737] {aka UNQ26, bet}, CSF2 (colony stimulating factor 2) [NCBI Gene 1437] {aka CSF, GMCSF}, CD28 (CD28 molecule) [NCBI Gene 940] {aka IMD123, Tp44}
- **Diseases:** gastric cancer (MESH:D013274), hematological malignancies (MESH:D019337), HNSCC (MESH:D000077195), hypoxia (MESH:D000860), T cell dysfunction (MESH:C536780), melanoma (MESH:D008545), mitochondrial dysfunction (MESH:D028361), cancer (MESH:D009369), breast cancer (MESH:D001943), liver metastases (MESH:D009362), B-ALL (MESH:D015456), cytotoxic (MESH:D064420)
- **Chemicals:** Metformin (MESH:D008687), pexidartinib (MESH:C000600259), lactate (MESH:D019344), durvalumab (MESH:C000613593), nivolumab (MESH:D000077594), glucose (MESH:D005947), CCX872 (-)
- **Species:** human gammaherpesvirus 4 (Epstein Barr virus, no rank) [taxon 10376], Homo sapiens (human, species) [taxon 9606]

## Full text

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Source: https://tomesphere.com/paper/PMC12936012