# Rehabilitation strategies for long COVID: integrating human factors engineering

**Authors:** Tzu-Sui Hung

PMC · DOI: 10.3389/fresc.2026.1708460 · Frontiers in Rehabilitation Sciences · 2026-02-12

## TL;DR

This paper explores how integrating human factors engineering into long COVID rehabilitation can improve patient-centered and effective interventions.

## Contribution

The novel contribution is introducing human factors engineering as a framework to optimize long COVID rehabilitation strategies.

## Key findings

- Telerehabilitation and cognitive ergonomics are emerging approaches that benefit from human factors integration.
- There is a lack of randomized controlled trials and standardized outcome measures in long COVID rehabilitation.
- Aligning rehabilitation with human factors engineering principles can enhance efficacy and patient engagement.

## Abstract

Long COVID presents unique challenges that extend beyond conventional biomedical rehabilitation, necessitating strategies that are adaptive, multidisciplinary, and patient-centered. This mini-review synthesizes current evidence on physical, cognitive, and occupational rehabilitation, and introduces human factors engineering as a framework to optimize the design, delivery, and usability of interventions. Emerging approaches such as telerehabilitation, cognitive ergonomics, and structured return-to-work programs illustrate the value of integrating clinical rehabilitation with user-centered design. Yet critical gaps remain, including the limited number of randomized controlled trials, the heterogeneity of outcome measures, and the lack of systematic integration between rehabilitation and human factors research. Addressing these challenges will be essential to develop effective, scalable, and sustainable interventions. By aligning rehabilitation protocols with the principles of human factors engineering, future practice can better enhance efficacy, promote sustained patient engagement, and ultimately improve the quality of life for individuals living with long COVID.

## Full-text entities

- **Diseases:** episodic disability (MESH:C580065), neuroinflammation (MESH:D000090862), dyspnea (MESH:D004417), neurodegenerative (MESH:D019636), orthostatic intolerance (MESH:D054971), hypoxia (MESH:D000860), autonomic dysfunction (MESH:D001342), chronic fatigue syndrome (MESH:D015673), Fatigue (MESH:D005221), infection (MESH:D007239), attention deficits (MESH:D001289), microvascular injury (MESH:D017566), postural orthostatic tachycardia syndrome (MESH:D054972), brain fog (MESH:D005222), Long COVID (MESH:D000094024), impaired memory (MESH:D008569), post-exertional malaise (MESH:D000092202), cardiac impairment (MESH:D006331)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## References

43 references — full list in the complete paper: https://tomesphere.com/paper/PMC12935956/full.md

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Source: https://tomesphere.com/paper/PMC12935956