# Mammary myofibroblastic sarcoma with lung metastasis: a case report and literature review

**Authors:** Miri Ryu, Youn Joo Jung, Seungju Lee, Seok Kyung Kang, Meehyun Lee, Jee Yeon Kim, Kyung Jin Nam, Kyeyoung Lee, Ji Hyeon Joo, Jae Joon Kim, Hyun Yul Kim

PMC · DOI: 10.3389/fsurg.2025.1698795 · Frontiers in Surgery · 2026-02-12

## TL;DR

A rare case of breast myofibroblastic sarcoma that spread to the lungs and eventually caused death is reported, highlighting the need for better treatment strategies.

## Contribution

This case report adds to the limited literature on mammary myofibroblastic sarcoma and its metastatic potential.

## Key findings

- A 55-year-old woman was diagnosed with low-grade myofibroblastic sarcoma of the breast.
- The tumor metastasized to the lungs and cervical lymph nodes, ultimately leading to the patient's death.
- No standard treatment guidelines exist due to the rarity of the disease.

## Abstract

Myofibroblastic sarcomas of the breast are rare, leading to very few reports on their prognosis and metastasis potential. We report a case of lung metastasis from a mammary low-grade myofibroblastic sarcoma. A 55-year-old woman with no remarkable past medical history presented to a local clinic with a palpable mass in her left breast that had persisted for 3 weeks. Vacuum-assisted excisional biopsy initially suggested a diagnosis of a malignant phyllodes tumor. Subsequent wide excision with clear surgical margins led to a confirmed diagnosis of myofibroblastic sarcoma. No additional treatments, such as chemotherapy or radiotherapy, were administered. Four years later, lung metastases were detected on chest computed tomography. The patient subsequently underwent wedge resection of the lung. Three years later, metastasis to the cervical lymph nodes was discovered. Owing to tumor emboli, the patient ultimately died from brain infarction. No consensus guidelines for standard treatment exist due to the scarcity of the disease. Although surgical resection remains the most reasonable treatment option, additional therapies should be considered to reduce the risk of metastatic spread to other organs.

## Linked entities

- **Diseases:** malignant phyllodes tumor (MONDO:0037003), brain infarction (MONDO:0005394)

## Full-text entities

- **Genes:** DES (desmin) [NCBI Gene 1674] {aka CDCD3, CSM1, CSM2, LGMD1D, LGMD1E, LGMD2R}, CD34 (CD34 molecule) [NCBI Gene 947], SMN1 (survival of motor neuron 1, telomeric) [NCBI Gene 6606] {aka BCD541, GEMIN1, SMA, SMA1, SMA2, SMA3}, PECAM1 (platelet and endothelial cell adhesion molecule 1) [NCBI Gene 5175] {aka CD31, CD31/EndoCAM, GPIIA', PECA1, PECAM-1, endoCAM}
- **Diseases:** LGMFS (MESH:D036821), tenderness (MESH:D063806), hemiplegia (MESH:D006429), lung and brain (MESH:C567034), lymph node metastases (MESH:D008207), infarction (MESH:D007238), breast cancer (MESH:D001943), LGMFS of the breast (MESH:D061325), bone metastases (MESH:D009362), hemangiopericytoma (MESH:D006393), Mammary myofibroblastic sarcoma (MESH:D012509), tumor emboli (MESH:D020766), mammary (MESH:D005348), phyllodes tumor (MESH:D003557), trauma (MESH:D014947), spindle cell neoplasms (MESH:D002277), lung (MESH:D008171), malignancies (MESH:D009369), brain infarction (MESH:D020520)
- **Chemicals:** hematoxylin (MESH:D006416)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12935901/full.md

## References

11 references — full list in the complete paper: https://tomesphere.com/paper/PMC12935901/full.md

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Source: https://tomesphere.com/paper/PMC12935901