# Editorial: Mechanopathology: unraveling the mechanical forces driving disease mechanisms

**Authors:** Cristina Bertocchi, Emanuele Rizzuto, Esther W. Gomez, Barbara Peruzzi

PMC · DOI: 10.3389/fcell.2026.1789070 · Frontiers in Cell and Developmental Biology · 2026-02-12

## Full-text entities

- **Genes:** Timp1 (tissue inhibitor of metalloproteinase 1) [NCBI Gene 21857] {aka Clgi, EPA, TIMP-1, TPA-S1, Timp}, Piezo1 (piezo-type mechanosensitive ion channel component 1) [NCBI Gene 234839] {aka 9630020g22, Fam38a, mKIAA0233}, Trpv4 (transient receptor potential cation channel, subfamily V, member 4) [NCBI Gene 63873] {aka 0610033B08Rik, OTRPC4, Trp12, VR-OAC, VRL-2, VROAC}, Piezo2 (piezo-type mechanosensitive ion channel component 2) [NCBI Gene 667742] {aka 5930434P17, 9030411M15Rik, 9430028L06Rik, Fam38b, Fam38b2}
- **Diseases:** tumorigenic (MESH:D002471), breast carcinoma (MESH:D001943), musculoskeletal degeneration (MESH:D009140), solid (MESH:D018250), pain (MESH:D010146), fibrosis (MESH:D005355), melanoma (MESH:D008545), inflammation (MESH:D007249), cancer (MESH:D009369), cartilage degeneration (MESH:D002357), hypoxia (MESH:D000860), PTOA (MESH:D004834), osteoarthritis (MESH:D010003)
- **Chemicals:** calcium (MESH:D002118)
- **Species:** Mus musculus (house mouse, species) [taxon 10090]

## Full text

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Source: https://tomesphere.com/paper/PMC12935865