# Optic Disc Pit Maculopathy Treated With Human Amniotic Membrane and Autologous Internal Limiting Membrane Flap: A Case Report

**Authors:** Prasan Rao, Anupama Rao, Ansu Sara John, Jabeen Mohammed Jaffer

PMC · DOI: 10.7759/cureus.102347 · Cureus · 2026-01-26

## TL;DR

A 23-year-old woman with optic disc pit maculopathy showed improved vision after a new surgical treatment combining human amniotic membrane and internal limiting membrane flap.

## Contribution

A novel surgical approach combining human amniotic membrane and autologous internal limiting membrane flap for optic disc pit maculopathy is presented.

## Key findings

- The patient showed significant anatomical and functional improvement after surgery.
- The treatment effects remained stable for one year of follow-up.

## Abstract

Optic disc pit (ODP)-associated maculopathy represents a rare and challenging condition with variable response to treatment. We report a case of a 23-year-old woman who underwent pars plana vitrectomy (PPV) with placement of a human amniotic membrane (hAM) patch along with an autologous internal limiting membrane (ILM) flap to treat ODP-associated macular detachment. Initial postoperative outcomes demonstrated significant anatomical and functional improvement, which remained stable for one year. This report highlights the potential benefits of combined hAM-assisted repair with autologous ILM flap for optic disc pit maculopathy and underscores the need for long-term follow-up and further refinement of surgical techniques.

## Full-text entities

- **Diseases:** vitreous detachment (MESH:D020255), retinal damage (MESH:D012164), outer (MESH:C538223), visual field defects (MESH:D005128), inflammatory (MESH:D007249), SRF (MESH:D006949), ODP (MESH:D009901), visual loss (MESH:D014786), glory disc anomaly (MESH:C535970), Maculopathy (MESH:D008268), cavitary anomalies (MESH:C566924), Chorioretinal scar (MESH:D002921), macular detachment (MESH:D012163), nerve (MESH:C537568), retinoschisis (MESH:D041441), macular hole (MESH:D012167)
- **Chemicals:** C3F8 (-), SF6 (MESH:D013459), perfluorocarbon (MESH:D005466)
- **Species:** Homo sapiens (human, species) [taxon 9606]
- **Cell lines:** hAM — Homo sapiens (Human), Finite cell line (CVCL_W388)

## Full text

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## Figures

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## References

17 references — full list in the complete paper: https://tomesphere.com/paper/PMC12935693/full.md

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Source: https://tomesphere.com/paper/PMC12935693