# Renal metastasis of esophageal squamous cell carcinoma coexisting with adenoid cystic carcinoma: a case report and literature review **Authors:** An-Qi Wu, Qiu-Hong Bao, Jian-Ming Pang, Qing-Qing Chen PMC · DOI: 10.3389/fonc.2026.1727349 · Frontiers in Oncology · 2026-02-12 ## TL;DR This paper reports a rare case of kidney metastasis from esophageal cancer coexisting with another cancer type. ## Contribution The novelty lies in documenting a rare coexistence of two cancer types with renal metastasis. ## Key findings - Renal metastasis from esophageal squamous cell carcinoma is uncommon. - The case involved coexistence with adenoid cystic carcinoma. - Such cases are rarely observed clinically and more often found in autopsies. ## Abstract Esophageal cancer is one of the common malignancies worldwide. It frequently metastasizes to the lungs and liver, as well as to distant sites such as bones, heart, and brain. Clinically, renal metastasis is rare, but it is more frequently observed in autopsy specimens. The present case report describes a rare case of renal metastasis from esophageal squamous cell carcinoma coexisting with adenoid cystic carcinoma. ## Linked entities - **Diseases:** esophageal squamous cell carcinoma (MONDO:0005580), adenoid cystic carcinoma (MONDO:0004971) ## Full-text entities - **Genes:** MUC16 (mucin 16, cell surface associated) [NCBI Gene 94025] {aka CA125}, AFP (alpha fetoprotein) [NCBI Gene 174] {aka AFPD, FETA, HPAFP}, KRT7 (keratin 7) [NCBI Gene 3855] {aka CK7, K2C7, K7, SCL}, KRT20 (keratin 20) [NCBI Gene 54474] {aka CD20, CK-20, CK20, K20, KRT21}, TP63 (tumor protein p63) [NCBI Gene 8626] {aka AIS, B(p51A), B(p51B), EEC3, KET, LMS}, ADA2 (adenosine deaminase 2) [NCBI Gene 51816] {aka ADGF, CECR1, IDGFL, PAN, SNEDS, VAIHS}, CEACAM3 (CEA cell adhesion molecule 3) [NCBI Gene 1084] {aka CD66D, CEA, CGM1, CGM1a, W264, W282}, MME (membrane metalloendopeptidase) [NCBI Gene 4311] {aka CALLA, CD10, CMT2T, NEP, SCA43, SFE}, GATA3 (GATA binding protein 3) [NCBI Gene 2625] {aka HDR, HDRS}, VIM (vimentin) [NCBI Gene 7431], KRT19 (keratin 19) [NCBI Gene 3880] {aka CK19, K19, K1CS}, KIT (KIT proto-oncogene, receptor tyrosine kinase) [NCBI Gene 3815] {aka C-Kit, CD117, MASTC, PBT, SCFR}, CA9 (carbonic anhydrase 9) [NCBI Gene 768] {aka CAIX, MN}, EGFR (epidermal growth factor receptor) [NCBI Gene 1956] {aka ERBB, ERBB1, ERRP, HER1, NISBD2, NNCIS}, CMPK1 (cytidine/uridine monophosphate kinase 1) [NCBI Gene 51727] {aka CK, CMK, CMPK, UMK, UMP-CMPK, UMPK}, LGALS3 (galectin 3) [NCBI Gene 3958] {aka CBP35, GAL3, GALBP, GALIG, L31, LGALS2} - **Diseases:** pain (MESH:D010146), hematuria (MESH:D006417), back pain (MESH:D001416), pancreatic cancer (MESH:D010190), melanoma (MESH:D008545), gallbladder stones (MESH:D005705), Metastasis to the (MESH:D009362), ACC (MESH:D003528), abdominal pain (MESH:D015746), weight loss (MESH:D015431), prostatic hyperplasia (MESH:D011470), ESCC (MESH:D000077277), gynecological tumors (MESH:D005833), lung cancer (MESH:D008175), cancer (MESH:D009369), primary (MESH:D010538), adenocarcinoma (MESH:D000230), lymphoma (MESH:D008223), lymph node metastasis (MESH:D008207), gastric cancer (MESH:D013274), kidney metastasis (MESH:D007674), breast cancer (MESH:D001943), Squamous cell carcinomas (MESH:D002294), renal mass (MESH:C536030), primary renal carcinomas (MESH:D002292), papillary carcinoma (MESH:D002291), fever (MESH:D005334), neuroendocrine tumor (MESH:D018358), Esophageal cancer (MESH:D004938), renal tumors (MESH:D007680) - **Chemicals:** carboplatin (MESH:D016190), platinum (MESH:D010984), H-E (MESH:D006371), FDG (MESH:D019788), paclitaxel (MESH:D017239) - **Species:** Homo sapiens (human, species) [taxon 9606] ## Full text _Full body text omitted from this summary view._ Fetch the complete paper as Markdown: https://tomesphere.com/paper/PMC12935646/full.md ## Figures 2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12935646/full.md ## References 20 references — full list in the complete paper: https://tomesphere.com/paper/PMC12935646/full.md --- Source: https://tomesphere.com/paper/PMC12935646