# Diagnosis and Management of Plummer–Vinson Syndrome in a Female Ghanaian

**Authors:** Dela Fiawoo, Theophilus Tandoh, Edeghonghon Olayemi

PMC · DOI: 10.1155/crh/7353717 · Case Reports in Hematology · 2026-02-25

## TL;DR

A 26-year-old Ghanaian woman with a long history of iron deficiency and swallowing difficulties was diagnosed with Plummer–Vinson syndrome and successfully treated.

## Contribution

This case highlights the occurrence of Plummer–Vinson syndrome in a younger, pregnant female from a region where the condition is rare.

## Key findings

- The patient showed improvement after oesophageal web dilatation and iron therapy.
- PVS was diagnosed in a young woman with a long-standing iron deficiency.
- The patient became pregnant three months after diagnosis.

## Abstract

Plummer–Vinson syndrome (PVS), also known as Paterson–Brown Kelly syndrome, is a clinical condition that is characterized by the triad of iron deficiency anemia, dysphagia and oesophageal web. This condition is rare and is diagnosed more in middle aged to older white women. However, in some studies, younger individuals have also been found to have this condition. We present a 26‐year‐old woman with a 5‐year history of progressive difficulty in swallowing and a long history (approximately 18 years) of iron deficiency anaemia and has been on intermittent iron supplementation. A barium swallow showed narrowing in the upper third of the oesophagus, and she underwent serial dilatation of the oesophageal web stenosis and iron therapy with resultant improvement in the dysphagia. This patient was found to be pregnant 3 months postdiagnosis of PVS. The prevalence of PVS has decreased due to early diagnosis of iron deficiency and repletion of iron stores.

## Linked entities

- **Diseases:** Plummer–Vinson syndrome (MONDO:0018895), iron deficiency anaemia (MONDO:0001356)

## Full-text entities

- **Diseases:** upper gastrointestinal cancers (MESH:D005770), heterotopic gastric mucosa (MESH:D002828), Chronic irritation of the oesophagus (MESH:D002908), anemia (MESH:D000740), spasm of the upper oesophagus (MESH:D013035), dysphagia (MESH:D003680), nutritional deficiencies (MESH:D044342), oesophageal web (MESH:C563636), precancerous condition (MESH:D011230), pharyngeal or oesophageal cancer (MESH:D010610), abnormal angulation of the oesophagus (MESH:C563330), upper gastrointestinal malignancies (MESH:D005767), Zenker's diverticulum (MESH:D016672), fatigue (MESH:D005221), oesophageal strictures (MESH:D003251), iron deficiency anemia (MESH:D018798), squamous cell carcinoma of the hypopharynx (MESH:D002294), difficulty (MESH:D051346), systemic sclerosis (MESH:D012595), iron (MESH:D000090463), esophageal webs (MESH:D004941), reflux oesophagitis (MESH:D005764), myasthenic (MESH:D020294), inflammation (MESH:D007249), glossitis (MESH:D005928), dysplasia (MESH:D015792), PVS (MESH:D011004), weakness (MESH:D018908), malignancy (MESH:D009369), achalasia (MESH:D004931), oesophageal burns (MESH:D000077277), atrophy (MESH:D001284)
- **Chemicals:** Barium (MESH:D001464), Leishman (-), Iron (MESH:D007501), ferrous sulphate (MESH:C020748)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

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## References

20 references — full list in the complete paper: https://tomesphere.com/paper/PMC12935298/full.md

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Source: https://tomesphere.com/paper/PMC12935298