# Incidental Intraplacental Choriocarcinoma in the Setting of Intrauterine Fetal Demise

## TL;DR

This case report describes a rare form of cancer found in the placenta after a fetal death and emphasizes the importance of examining the placenta for better clinical guidelines.

## Contribution

The paper presents a rare case of intraplacental choriocarcinoma following intrauterine fetal demise and highlights the need for placental examination in clinical practice.

## Key findings

- Intraplacental choriocarcinoma was diagnosed following intrauterine fetal demise.
- Placental examination is crucial for identifying rare gestational trophoblastic neoplasia cases.
- Clinical management relied on serum β-hCG levels for surveillance.

## Abstract

Gestational trophoblastic neoplasia (GTN) is a rare group of pregnancy‐related diseases involving the abnormal transformation of placental cells with metastatic potential. GTN includes choriocarcinomas, epithelioid trophoblastic tumors, placental site trophoblastic tumors, and invasive moles. The clinical presentation of GTN is often indolent and ultimately fatal if left untreated. Given the presentation of GTN and its low incidence, clinical care and proposed guidelines for managing GTN are limited, with a primary reliance on serum β‐hCG levels for treatment and surveillance. In this case report, we describe a case of intraplacental choriocarcinoma (IC) in the setting of intrauterine fetal demise (IUFD). We share the histopathologic diagnosis, the clinical management and surveillance for residual disease, and highlight the importance of placental examination for the purposes of building out clinical practice guidelines.