# Antimicrobial and Cytotoxic Activities of Biogenic Nanoparticles Produced by Cyanobacteria

**Authors:** Laíne Santos Ribeiro, Rhuana Valdetário Médice, Janaína Morone Bavini, Camila Manoel Crnkovic, Samuel Cavalcante do Amaral

PMC · DOI: 10.1002/cbic.202500882 · Chembiochem · 2026-02-25

## TL;DR

This paper reviews how nanoparticles made by cyanobacteria can fight microbes and cancer cells, offering potential for new therapies.

## Contribution

The paper provides a comprehensive review of the antimicrobial and cytotoxic properties of cyanobacteria-derived nanoparticles.

## Key findings

- Cyanobacteria-derived nanoparticles show antimicrobial activity against both Gram-positive and Gram-negative bacteria and fungi.
- These nanoparticles induce apoptosis in tumor cells, suggesting potential in cancer therapy.
- Their biocompatibility and structural diversity make them promising for biotechnological applications.

## Abstract

Biogenic nanoparticles are distinguished by their unique physical and chemical attributes, notably their potent antimicrobial activity against bacterial and fungal pathogens, as well as their cytotoxic effects on cancer cells. These nanoparticles are characterized by their biocompatibility, indicating their potential as effective antimicrobial agents and in oncological therapies. This article examines the existing literature on the antimicrobial and cytotoxic properties of nanoparticles derived from cyanobacteria, with particular emphasis on their implications for human health.

The article reviews the green synthesis of biogenic nanoparticles produced by cyanobacteria, highlighting their antimicrobial and cytotoxic properties. These nanoparticles, formed intra‐ or extracellularly, show activity against Gram‐positive and Gram‐negative bacteria as well as fungi and can induce apoptosis in tumor cells. With biocompatibility and structural diversity, they emerge as promising alternatives in biotechnology and cancer therapies.© 2026 WILEY‐VCH GmbH

## Linked entities

- **Diseases:** cancer (MONDO:0004992)

## Full-text entities

- **Genes:** DNAH8 (dynein axonemal heavy chain 8) [NCBI Gene 1769] {aka ATPase, SPGF46, hdhc9}, TP53 (tumor protein p53) [NCBI Gene 7157] {aka BCC7, BMFS5, LFS1, P53, TRP53}
- **Diseases:** Liver Cancer (MESH:D006528), fungal (MESH:D009181), MRSA (MESH:D013203), deformities (MESH:D009140), Breast Cancer (MESH:D001943), Cytotoxic (MESH:D064420), epithelial adenocarcinoma (MESH:D009375), deaths (MESH:D003643), Colon Cancer (MESH:D015179), hyperthermia (MESH:D005334), nonsmall cell lung cancer (MESH:D002289), cervical squamous cell carcinoma (MESH:D002294), colon adenocarcinoma (MESH:D003110), beta-thalassemia (MESH:D017086), Lung Cancer (MESH:D008175), mammary adenocarcinoma (MESH:D000230), cancer (MESH:D009369), inflammatory (MESH:D007249), Cervical Cancer (MESH:D002583), mitochondrial dysfunction (MESH:D028361)
- **Chemicals:** NADH (MESH:D009243), hydrogen (MESH:D006859), alcohols (MESH:D000438), chloramphenicol (MESH:D002701), ROS (MESH:D017382), fluconazole (MESH:D015725), cobalt (MESH:D003035), Titanium Oxide (MESH:C009495), lipid (MESH:D008055), lipopolysaccharides (MESH:D008070), OH (MESH:C031356), Amphotericin B (MESH:D000666), Na2SeO3 (MESH:D018038), titanium (MESH:D014025), starch (MESH:D013213), Selenium (MESH:D012643), fatty acids (MESH:D005227), carbohydrate (MESH:D002241), superoxide (MESH:D013481), AuNPs (-), hydrogen peroxide (MESH:D006861), cefotaxime (MESH:D002439), adriamycin (MESH:D004317), sodium citrate (MESH:D000077559), tetracycline (MESH:D013752), Ag+ (MESH:D012834), tobramycin (MESH:D014031), alkanes (MESH:D000473), Iron oxide (MESH:C000499), polyvinylpyrrolidone (MESH:D011205), Copper (MESH:D003300), ascorbate (MESH:D001205), alkaloids (MESH:D000470), cholesterol (MESH:D002784), methicillin (MESH:D008712), aldehyde (MESH:D000447), CHO (MESH:C034482), hydroxyl (MESH:D017665), water (MESH:D014867), 5-FU (MESH:D005472), amide (MESH:D000577), Zinc Oxide (MESH:D015034), methylcellulose (MESH:D008747), carotenoids (MESH:D002338), sodium borohydride (MESH:C025364), iron (MESH:D007501), Polysaccharides (MESH:D011134), NaAuCl4 (MESH:C024568), agar (MESH:D000362), chlorophyll (MESH:D002734), silver nitrate (MESH:D012835), C (MESH:D002244), metal (MESH:D008670), silver NP (MESH:C586932), gold (MESH:D006046), chitosan (MESH:D048271), nitrate (MESH:D009566), Zinc (MESH:D015032), sulfate (MESH:D013431)
- **Species:** Chroococcus turgidus (species) [taxon 380547], Klebsiella aerogenes (species) [taxon 548], Botrytis cinerea (gray fruit mold, species) [taxon 40559], Pseudanabaena (genus) [taxon 1152], Proteus vulgaris (species) [taxon 585], Kamptonema formosum (species) [taxon 331992], Fusarium sp. (species) [taxon 29916], Fusarium oxysporum (species) [taxon 5507], Synechocystis sp. (species) [taxon 1143], Oscillatoria salina (species) [taxon 331517], Alternaria alternata (species) [taxon 5599], Human papillomavirus 16 (serotype) [taxon 333760], Nostoc (genus) [taxon 1177], Streptococcus sp. (species) [taxon 1306], Nostoc sp. HKAR-2 (species) [taxon 640324], Microcystis aeruginosa (species) [taxon 1126], Rhizopus microsporus (species) [taxon 58291], Acinetobacter baumannii (species) [taxon 470], Oscillatoria sp. (species) [taxon 1159], PX clade (clade) [taxon 569578], Aspergillus versicolor (species) [taxon 46472], Nostoc linckia (species) [taxon 92942], Staphylococcus aureus (species) [taxon 1280], Bacteria Latreille et al. 1825 (Bacteria stick insect, genus) [taxon 629395], Homo sapiens (human, species) [taxon 9606], Staphylococcus epidermidis (species) [taxon 1282], Nostoc carneum (species) [taxon 374162], Desertifilum sp. (species) [taxon 2497424], Phormidium sp. (species) [taxon 1199], Trichodesmium erythraeum (species) [taxon 1206], Plectonema sp. (species) [taxon 29414], Nostoc sp. (species) [taxon 1180], Aspergillus flavus (species) [taxon 5059], Cercopithecidae (monkey, family) [taxon 9527], Bacillus safensis (species) [taxon 561879], Klebsiella oxytoca (species) [taxon 571], Spirulina (suborder) [taxon 551299], Leptolyngbya sp. (species) [taxon 47254], Streptococcus pyogenes (species) [taxon 1314], Pseudomonas aeruginosa PAO1 (strain) [taxon 208964], Klebsiella sp. (species) [taxon 576], Streptococcus pneumoniae (species) [taxon 1313], Dolichospermum spiroides (species) [taxon 135104], Anabaena iyengarii (species) [taxon 518123], Salmonella enterica subsp. enterica serovar Typhimurium (no rank) [taxon 90371], Fungi (kingdom) [taxon 4751], Trichoderma harzianum (species) [taxon 5544], Microcystis sp. (species) [taxon 1127], Cyanobacteriota (blue-green algae, phylum) [taxon 1117], Enterococcus faecalis (species) [taxon 1351], Enterococcus hirae (species) [taxon 1354], Anabaena sp. (species) [taxon 1167], Cyanothece (genus) [taxon 43988], [Leptolyngbya] sp. JSC-1 (species) [taxon 1487953], Trichophyton rubrum (species) [taxon 5551], Pseudomonas aeruginosa (species) [taxon 287], Nakaseomyces glabratus (species) [taxon 5478], Human papillomavirus (species) [taxon 10566], Cylindrospermum stagnale (species) [taxon 142864], Nodosilinea nodulosa (species) [taxon 416001]
- **Cell lines:** NCCU-442 — Homo sapiens (Human), Finite cell line (CVCL_V772), Lukesova 2/91 — Mus musculus (Mouse), Spontaneously immortalized cell line (CVCL_B9UW), Vero — Chlorocebus sabaeus (Green monkey), Spontaneously immortalized cell line (CVCL_0059), HFs — Mus musculus (Mouse), Spontaneously immortalized cell line (CVCL_0594), MTCC443 — Homo sapiens (Human), Trichothiodystrophy, Transformed cell line (CVCL_2562), HeLa — Homo sapiens (Human), Human papillomavirus-related cervical squamous cell carcinoma, Cancer cell line (CVCL_T292), HEK-293 — Homo sapiens (Human), Transformed cell line (CVCL_0045), T47D — Homo sapiens (Human), Invasive breast carcinoma of no special type, Cancer cell line (CVCL_0553), HCT-166 — Homo sapiens (Human), Supernumerary circular chromosome, Finite cell line (CVCL_V754), SW480 — Homo sapiens (Human), Colon adenocarcinoma, Cancer cell line (CVCL_0546), MRC-5 — Homo sapiens (Human), Finite cell line (CVCL_0440), MDA-MB-231 — Homo sapiens (Human), Breast adenocarcinoma, Cancer cell line (CVCL_0062), HKAR-2 — Homo sapiens (Human), Colon carcinoma, Cancer cell line (CVCL_A628), Caco-2 — Homo sapiens (Human), Colon adenocarcinoma, Cancer cell line (CVCL_0025), WI38 — Homo sapiens (Human), Finite cell line (CVCL_0579), MCF-7 — Homo sapiens (Human), Invasive breast carcinoma of no special type, Cancer cell line (CVCL_0031), WISH — Homo sapiens (Human), Human papillomavirus-related endocervical adenocarcinoma, Cancer cell line (CVCL_1909), H1299 — Homo sapiens (Human), Lung large cell carcinoma, Cancer cell line (CVCL_0060), SOSA-4 — Homo sapiens (Human), Ataxia telangiectasia syndrome, Finite cell line (CVCL_F083), HF — Homo sapiens (Human), Diffuse large B-cell lymphoma germinal center B-cell type, Cancer cell line (CVCL_UI84), HCT-116 — Homo sapiens (Human), Colon carcinoma, Cancer cell line (CVCL_0291), MCF-7/ADR — Homo sapiens (Human), High grade ovarian serous adenocarcinoma, Cancer cell line (CVCL_1452), WI-83 — Homo sapiens (Human), Glioblastoma, Cancer cell line (CVCL_C6IZ), SiHa — Homo sapiens (Human), Human papillomavirus-related cervical squamous cell carcinoma, Cancer cell line (CVCL_0032), A549 — Homo sapiens (Human), Lung adenocarcinoma, Cancer cell line (CVCL_0023), HepG2 — Homo sapiens (Human), Hepatoblastoma, Cancer cell line (CVCL_0027), PCC 7120 — Rattus norvegicus (Rat), Hybridoma (CVCL_A6HN)

## Full text

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## Figures

5 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12935092/full.md

## References

163 references — full list in the complete paper: https://tomesphere.com/paper/PMC12935092/full.md

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Source: https://tomesphere.com/paper/PMC12935092