# Research progress on biological functions of astragalus stems and leaves and their application in cattle production: a review

**Authors:** Chunfang Ma, Jinbao Zhang, Qi Yang, Qiaoe Zhang

PMC · DOI: 10.1080/10495398.2026.2631838 · Animal Biotechnology · 2026-02-24

## TL;DR

Astragalus stems and leaves are a nutritious and cost-effective feed additive that can improve cattle health and production.

## Contribution

This review compiles the biological functions and applications of Astragalus stems and leaves in cattle production.

## Key findings

- Astragalus stems and leaves contain bioactive compounds like polysaccharides and flavonoids with antioxidant and anti-inflammatory properties.
- They offer a low-cost alternative feedstuff that can enhance cattle health and reduce feeding costs.
- ASL can support animal nutrition regulation and forage development in cattle production.

## Abstract

Astragalus stems and leaves (ASL) represent a promising feed additive to improve cattle health and production efficiency. They are rich in nutrients and active substances, such as polysaccharides, flavonoids, alkaloids, exhibit antioxidant, antibacterial, anti-inflammatory, and other biological functions. With the advantages of high yield and low price, ASL are excellent potential feedstuff resources that could alleviate the shortage of conventional feed and reduce feeding costs. This review highlights the botanical characteristics, phytochemical components, nutritional and pharmacological effects of ASL, as well as their applications in cattle production, which could be beneficial for animal nutrition regulation and forage development.

## Full-text entities

- **Genes:** IFNG (interferon gamma) [NCBI Gene 281237], BCL2 (BCL2 apoptosis regulator) [NCBI Gene 281020], PIK3CA (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha) [NCBI Gene 282306], INS (insulin) [NCBI Gene 280829], IL2 (interleukin 2) [NCBI Gene 280822] {aka IL-2, TCGF}, Pde3b (phosphodiesterase 3B, cGMP-inhibited) [NCBI Gene 18576] {aka 9830102A01Rik}, CASP3 (caspase 3) [NCBI Gene 408016], Akt1 (Akt serine/threonine kinase 1) [NCBI Gene 11651] {aka Akt, LTR-akt, PKB, PKB/Akt, PKBalpha, Rac}, cytochrome C [NCBI Gene 104968582], CD4 (CD4 molecule) [NCBI Gene 407098], TLR4 (toll like receptor 4) [NCBI Gene 281536], TNF (tumor necrosis factor) [NCBI Gene 280943] {aka TNF-a, TNF-alpha, TNFa}, BAX (BCL2 associated X, apoptosis regulator) [NCBI Gene 280730], LOC517016 (interleukin 6 (interferon, beta 2)) [NCBI Gene 517016] {aka IF1DA6}, CAT (catalase) [NCBI Gene 531682]
- **Diseases:** inflammation (MESH:D007249), lung fibrosis (MESH:D005355), lipid metabolism disorders (MESH:D052439), pancreatic cancer (MESH:D010190), lung cancer (MESH:D008175), infection (MESH:D007239), cancer (MESH:D009369), diabetes (MESH:D003920), toxicity (MESH:D064420), renal toxicity (MESH:D007674), gastric cancer (MESH:D013274), liver toxicity (MESH:D056486), diarrhea (MESH:D003967), APS (MESH:C564877), vacuolar degeneration (MESH:C536522), mastitis (MESH:D008413), infectious diseases (MESH:D003141), sepsis (MESH:D018805)
- **Chemicals:** APS-A1 (-), isorhamnetin-3-O-neohesperidoside (MESH:C469309), linoleic acid (MESH:D019787), salts (MESH:D012492), phosphorus (MESH:D010758), K (MESH:D011188), urobilin (MESH:D014557), betaine (MESH:D001622), Na (MESH:D012964), Zn (MESH:D015032), niacin (MESH:D009525), aspartic acid (MESH:D001224), Polysaccharide (MESH:D011134), nitrogen (MESH:D009584), Amino acid (MESH:D000596), choline (MESH:D002794), isoquercetin (MESH:C016527), astragalin (MESH:C001579), starch (MESH:D013213), riboflavin (MESH:D012256), galacturonic acid (MESH:C007819), DPPH (MESH:C004931), malondialdehyde (MESH:D008315), vitamin P (MESH:D012431), selenium (MESH:D012643), hypericin (MESH:C004965), creatine (MESH:D003401), water (MESH:D014867), fructose (MESH:D005632), linolenic acid (MESH:D017962), phenolic acids (MESH:C017616), Fe (MESH:D007501), lipid (MESH:D008055), sterols (MESH:D013261), coumarin (MESH:C030123), AsIV (MESH:C052064), gypsum (MESH:D002133), Cycloastragenol (MESH:C061014), glutamic acid (MESH:D018698), isorhamnetin (MESH:C047368), vitamin C (MESH:D001205), caffeic acid (MESH:C040048), Alkaloids (MESH:D000470), Cu (MESH:D003300), Flavonoids (MESH:D005419), 2-keto butyric acid (MESH:C005087), ethanol (MESH:D000431), chlorogenic acid (MESH:D002726), glucose (MESH:D005947), Saponins (MESH:D012503), folic acid (MESH:D005492), reactive oxygen species (MESH:D017382), glycosides (MESH:D006027), Ca (MESH:D002118), glycine (MESH:D005998), blood sugar (MESH:D001786)
- **Species:** Escherichia coli (E. coli, species) [taxon 562], Carassius auratus (goldfish, species) [taxon 7957], Mus musculus (house mouse, species) [taxon 10090], Homo sapiens (human, species) [taxon 9606], Saccharomyces cerevisiae (baker's yeast, species) [taxon 4932], Bos taurus (bovine, species) [taxon 9913], Gallus gallus (bantam, species) [taxon 9031], Astragalus (genus) [taxon 20400], Porcine circovirus 2 (no rank) [taxon 85708]
- **Cell lines:** MGC-803 — Homo sapiens (Human), Hybrid cell line (CVCL_5334)

## Full text

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## Figures

6 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12934339/full.md

## References

85 references — full list in the complete paper: https://tomesphere.com/paper/PMC12934339/full.md

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Source: https://tomesphere.com/paper/PMC12934339