# A Case Report of Postpartum Hemorrhage Secondary to Snake Bite Envenomation: A Pathogenesis and Current Management Review

**Authors:** Felipe Loza-Hernandez, Alexis Haro, Gabriela Carrión, Homero Loza

PMC · DOI: 10.1155/crog/1956143 · Case Reports in Obstetrics and Gynecology · 2026-02-25

## TL;DR

A pregnant woman in Ecuador suffered severe postpartum bleeding after a snakebite, highlighting the dangers of snake venom during pregnancy and the need for better treatment access.

## Contribution

This case report provides new insights into managing snakebite-induced coagulopathy during pregnancy and emphasizes the need for improved antivenom access.

## Key findings

- Snakebite during pregnancy can lead to severe coagulopathy and postpartum hemorrhage requiring hysterectomy.
- Standard coagulation tests may be insufficient for diagnosing venom-induced coagulopathy.
- Early antivenom administration and multidisciplinary care are critical for improving maternal outcomes.

## Abstract

Snakebite envenomation (SBE) is a tropical disease with significant global morbidity and mortality, particularly affecting low‐resource settings. During pregnancy, SBE poses unique challenges, increasing both maternal and fetal mortality. Limited access to antivenom and delayed treatment further worsen outcomes.

We report the case of a 36‐year‐old pregnant woman at 40.6 weeks gestation who presented to a rural Ecuadorian health center following a Bothrops snakebite to the right hand. Coagulopathy was detected and initially managed with antivenom. Because of fetal distress and oligohydramnios, an urgent cesarean section was performed. The patient subsequently developed severe postpartum hemorrhage secondary to venom‐induced coagulopathy (VICC), requiring subtotal hysterectomy, intensive care, and further antivenom administration. Postoperative recovery was favorable, and the patient was discharged in stable condition.

This case illustrates the complex pathophysiology of viper envenomation, including systemic coagulopathy, uterine atony, and thrombin‐induced postpartum hemorrhage. It highlights the diagnostic challenges, the limitations of standard coagulation tests in VICC, and the importance of early antivenom therapy. Delayed treatment in rural areas contributes significantly to maternal‐fetal morbidity. Obstetric complications such as placental abruption, fetal hypoxia, and hemorrhage must be anticipated in SBE during pregnancy.

Timely antivenom administration and multidisciplinary management are essential to improve outcomes in pregnant patients with SBE. This case emphasizes the need for increased access to antivenom, improved diagnostic tools, and specialized obstetric care in resource‐limited regions affected by venomous snakebites.

## Linked entities

- **Diseases:** snakebite envenomation (MONDO:0018669), coagulopathy (MONDO:0001531)
- **Species:** Bothrops (taxon 8721)

## Full-text entities

- **Genes:** PLA2G2A (phospholipase A2 group IIA) [NCBI Gene 5320] {aka MOM1, PLA2, PLA2B, PLA2L, PLA2S, PLAS1}, MB (myoglobin) [NCBI Gene 4151] {aka MYOSB, PVALB}, F2 (coagulation factor II, thrombin) [NCBI Gene 2147] {aka PT, RPRGL2, THPH1}, PLA2G1B (phospholipase A2 group IB) [NCBI Gene 5319] {aka PLA2, PLA2A, PPLA2}, FGB (fibrinogen beta chain) [NCBI Gene 2244] {aka HEL-S-78p}, FN1 (fibronectin 1) [NCBI Gene 2335] {aka CIG, ED-B, FINC, FN, FNZ, GFND}
- **Diseases:** consumption coagulopathy (MESH:D004211), neurological deterioration (MESH:D009422), tissue (MESH:D017695), hemolysis (MESH:D006461), polydactyly (MESH:D017689), anaphylaxis (MESH:D000707), hypofibrinogenemia (MESH:D000347), abruptio placentae (MESH:D000037), hypoxia (MESH:D000860), hyperpyrexia (MESH:D000084462), preterm labor (MESH:D007752), myotoxicity (MESH:D000081030), hydrocephalus (MESH:D006849), distress (MESH:D012128), necrosis (MESH:D009336), TMA (MESH:D057049), paralysis (MESH:D010243), Postpartum Hemorrhage (MESH:D006473), AKI (MESH:D058186), fetal abnormalities (MESH:D005315), fetal and neonatal death (MESH:D005313), hypersensitivity (MESH:D004342), respiratory failure (MESH:D012131), intracranial hemorrhage (MESH:D020300), bruising (MESH:D003288), stillbirth (MESH:D050497), heart failure (MESH:D006333), renal injury (MESH:D007674), depressive disorders (MESH:D003866), Hemorrhage (MESH:D006470), lacerations (MESH:D022125), psychological disorders (MESH:D000067073), hemo-toxicity (MESH:D064420), hyperkeratosis (MESH:D017488), hypovolemia (MESH:D020896), chronic kidney disease (MESH:D051436), edema (MESH:D004487), venom (MESH:D000092422), Bothrops snakebite (MESH:D012909), Bite Envenomation (MESH:D001733), envenomation (MESH:D065008), Coagulopathy (MESH:D001778), neurotoxic (MESH:D020258), renal tubular and cortical necrosis (MESH:D007683), infection (MESH:D007239), microangiopathy (MESH:D014652), placental bleeding (MESH:D010922), thrombocytopenia (MESH:D013921), pain (MESH:D010146), uterine rupture (MESH:D014597), deaths (MESH:D003643), cerebral hemorrhage (MESH:D002543), clotting-factor deficiency (MESH:C564885), compartmental syndrome (MESH:D013577), renal long-term injury (MESH:D000088562), trauma (MESH:D014947), cardiovascular shock (MESH:D012769), oligohydramnios (MESH:D016104), inflammatory (MESH:D007249), muscle damage (MESH:D009133)
- **Chemicals:** Varespladib (MESH:C117948), glycerophospholipids (MESH:D020404), kaolin (MESH:D007616), metal (MESH:D008670), D (MESH:D003903), celite (MESH:D007692), ASV (-)
- **Species:** Ovis aries (domestic sheep, species) [taxon 9940], Equus caballus (domestic horse, species) [taxon 9796], Bothrops (genus) [taxon 8721], Equus asinus (African ass, species) [taxon 9793], Homo sapiens (human, species) [taxon 9606], Vipera berus berus (common viper, subspecies) [taxon 31156], Serpentes (snakes, infraorder) [taxon 8570]

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## References

40 references — full list in the complete paper: https://tomesphere.com/paper/PMC12933875/full.md

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Source: https://tomesphere.com/paper/PMC12933875