# Long‐Term Impact of EGUIDE Training on Facility‐Wide Guideline Adherence Rate in Schizophrenia and Major Depressive Disorder—A Methodological Reflection

**Authors:** Ghufran Saeed Rizvi

PMC · DOI: 10.1002/npr2.70103 · Neuropsychopharmacology Reports · 2026-02-25

## TL;DR

This paper points out methodological issues in a study about training effects on mental health treatment guidelines and suggests better research approaches.

## Contribution

The paper introduces methodological recommendations to improve future evaluations of training programs in clinical settings.

## Key findings

- The original study had selection bias and ignored data clustering.
- Quasiexperimental designs and multilevel modeling are recommended for future research.
- Patient-centered outcomes should be prioritized to assess clinical effectiveness accurately.

## Abstract

This Letter highlights crucial methodological flaws, including selection bias and ignored data clustering, in the EGUIDE training impact study. We recommend adopting quasiexperimental designs, multilevel modeling, and patient‐centered outcomes to ensure future research accurately confirms the program's true clinical effectiveness.

## Linked entities

- **Diseases:** schizophrenia (MONDO:0005090), Major Depressive Disorder (MONDO:0002009)

## Full-text entities

- **Diseases:** Major Depressive Disorder (MESH:D003865), Schizophrenia (MESH:D012559), psychiatric (MESH:D001523)
- **Chemicals:** EGUIDE (-)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

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## References

9 references — full list in the complete paper: https://tomesphere.com/paper/PMC12933874/full.md

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Source: https://tomesphere.com/paper/PMC12933874