# Photocatalytic multicomponent alkene dicarbofunctionalization via PCET/nickel dual catalysis

## TL;DR

A new catalytic method uses light and nickel to convert alcohols into complex molecules by adding two carbon groups to alkenes.

## Contribution

The first enantioselective PCET-mediated transformation using a chiral nickel catalyst for alkene dicarbofunctionalization.

## Key findings

- The method enables three-component alkene dicarbofunctionalization using unprotected alcohols as alkyl radical precursors.
- It achieves C(sp3)–C(sp3) and C(sp3)–C(sp2) bond formation under visible light and redox-neutral conditions.
- The approach shows broad functional-group tolerance and works with secondary and tertiary alcohols.

## Abstract

Herein we report a synergistic photoredox PCET/nickel dual catalytic strategy that enables three-component alkene dicarbofunctionalization (DCF) using unprotected alcohols as alkyl radical precursors. This transformation merges concerted proton-coupled electron transfer (PCET) activation of alcohols with nickel-catalyzed cross-coupling, achieving sequential Giese addition and C(sp3)–C(sp3), C(sp3)–C(sp2) bond formation under visible light and redox-neutral conditions. The method proceeds directly from secondary and tertiary alcohols, exhibits broad functional-group tolerance. Notably, employing a chiral Ni catalyst enables the first enantioselective variant of this type of PCET mediated transformation. This work establishes a general platform for deconstructive alkene difunctionalization from simple alcohol feedstocks, expanding the synthetic reach of PCET in dual catalytic radical chemistry.

Herein we report a synergistic photoredox PCET/nickel dual catalytic strategy that enables three-component alkene dicarbofunctionalization (DCF) using unprotected alcohols as alkyl radical precursors.