# Fatal Necrotizing Fasciitis Caused by Pasteurella multocida Without Cutaneous Findings: When Pain Is the Clue

**Authors:** David J Vogt, Vanessa Frey, Ruth Valek, Roberto Buonomano

PMC · DOI: 10.7759/cureus.102296 · Cureus · 2026-01-26

## TL;DR

A rare case of fatal necrotizing fasciitis caused by a cat/dog-related bacteria was identified, emphasizing the importance of recognizing severe pain as a key early sign.

## Contribution

Highlights the diagnostic challenge of necrotizing fasciitis caused by Pasteurella multocida without visible skin symptoms.

## Key findings

- Necrotizing fasciitis caused by Pasteurella multocida occurred without skin changes or imaging clues.
- Severe localized pain was the primary early symptom in this case.
- Post-mortem analysis confirmed the presence of Pasteurella multocida in the patient.

## Abstract

We report a case of fatal necrotizing fasciitis in an elderly woman presenting with severe right upper-arm pain and elevated inflammatory markers in the absence of apparent skin changes or diagnostic imaging findings. Despite broad-spectrum antimicrobial therapy and supportive care, the patient deteriorated rapidly and died within 24 hours of hospital admission.

Post-mortem blood cultures identified Pasteurella multocida, a zoonotic pathogen commonly found in cats and dogs. Retrospective review of the initial CT scan revealed fascial edema and soft tissue stranding, compatible with necrotizing fasciitis. Necrotizing fasciitis caused by P. multocida is exceedingly rare, particularly in the absence of skin disruption or penetrating injury. Close contact with household animals can enable non-bite transmission.

This case highlights an important diagnostic pitfall: severe, localized pain out of proportion to physical findings may be the only early clinical sign of necrotizing fasciitis. Clinicians should remain vigilant for deep soft-tissue infection in septic patients presenting with disproportionate pain, as early recognition, interdisciplinary management, and prompt surgical intervention are essential to improve outcomes.

## Linked entities

- **Diseases:** necrotizing fasciitis (MONDO:0004835)
- **Species:** Pasteurella multocida (taxon 747)

## Full-text entities

- **Genes:** CRP (C-reactive protein) [NCBI Gene 1401] {aka PTX1}
- **Diseases:** Pain (MESH:D010146), hematuria (MESH:D006417), Necrotizing Fasciitis (MESH:D019115), soft-tissue infections (MESH:D018461), respiratory infections (MESH:D012141), circulatory collapse (MESH:D012769), inflammatory (MESH:D007249), meningitis (MESH:D008580), ecchymosis (MESH:D004438), edema (MESH:D004487), anuric renal failure (MESH:D051437), SIRS (MESH:D018746), diabetes mellitus (MESH:D003920), lactic acidosis (MESH:D000140), cardiomyopathy (MESH:D009202), hypoalbuminemia (MESH:D034141), acute kidney injury (MESH:D058186), hypoxemic (MESH:D012131), cutaneous abnormalities (MESH:D018366), leukopenia (MESH:D007970), Organ Failure (MESH:D009102), tachycardia (MESH:D013610), hypotension (MESH:D007022), ischemia (MESH:D007511), skin discoloration (MESH:D014075), Fascial edema (MESH:C563219), death (MESH:D003643), hypothyroidism (MESH:D007037), bullae (MESH:D001768), respiratory and gastrointestinal diseases (MESH:D012818), thrombosis (MESH:D013927), urinary tract infection (MESH:D014552), metabolic acidosis (MESH:D000138), infection (MESH:D007239), thrombocytopenia (MESH:D013921), atrial fibrillation (MESH:D001281), bacteremia (MESH:D016470), liver failure (MESH:D017093), erysipelas (MESH:D004886), type 2 diabetes mellitus (MESH:D003924), phlegmones (MESH:D002481), degenerative musculoskeletal changes (MESH:D009140), endocarditis (MESH:D004696), anuric kidney injury (MESH:D007674), skin abnormalities (MESH:D012868), Sepsis (MESH:D018805), infectious (MESH:D003141), septic shock (MESH:D012772), erythema (MESH:D004890), septic (MESH:D001170), necrosis (MESH:D009336)
- **Chemicals:** oxygen (MESH:D010100), lactate (MESH:D019344), amoxicillin-clavulanate (MESH:D019980), Clindamycin (MESH:D002981), norepinephrine (MESH:D009638), dobutamine (MESH:D004280), cephalosporins (MESH:D002511), piperacillin-tazobactam (MESH:D000077725), nitrite (MESH:D009573), lipopolysaccharide (MESH:D008070), creatinine (MESH:D003404), beta-lactams (MESH:D047090)
- **Species:** Canis lupus familiaris (dog, subspecies) [taxon 9615], Felis catus (cat, species) [taxon 9685], Homo sapiens (human, species) [taxon 9606], Pasteurella multocida (species) [taxon 747]

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## References

26 references — full list in the complete paper: https://tomesphere.com/paper/PMC12933506/full.md

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Source: https://tomesphere.com/paper/PMC12933506