# Distant Metastases of an Atypical Meningioma 14 Years Later After Primary Tumor Resection: A Case Report and Review of the Literature

**Authors:** Kassaye Firde, Douglas Flieder, Maria Gonzalez, Laura Barry, Alessandro Bombonati, Israh Akhtar, Ibrahim Khalifeh, Curtis Miyamoto, Yuan Rong

PMC · DOI: 10.1155/crip/5717203 · Case Reports in Pathology · 2026-02-25

## TL;DR

A rare case of atypical meningioma leading to distant metastases 14 years after initial surgery is reported and reviewed.

## Contribution

This case report highlights the long-term metastatic potential of atypical meningiomas despite prior treatment.

## Key findings

- Extracranial metastases occurred 14 years after primary tumor resection.
- The patient had intracranial recurrence followed by multiple radiation therapies.
- Such distant metastases are rare, occurring in less than 1% of meningioma cases.

## Abstract

Meningioma, one of the most common neoplasms of the central nervous system in adults, is most likely derived from the meningothelial cells of the arachnoid matter. Although most meningiomas have a benign clinical course and a relatively good prognosis, some can demonstrate more aggressive biological features, including local invasion and distant metastases. Extracranial meningioma metastases are rare, occurring in less than 1% of cases. We present a case of atypical meningioma status post resection with intracranial recurrence followed by multiple radiation therapies who developed extracranial metastases 14 years after primary tumor resection.

## Linked entities

- **Diseases:** meningioma (MONDO:0003057)

## Full-text entities

- **Genes:** CDKN2A (cyclin dependent kinase inhibitor 2A) [NCBI Gene 1029] {aka ARF, CAI2, CDK4I, CDKN2, CMM2, INK4}, NOTCH3 (notch receptor 3) [NCBI Gene 4854] {aka CADASIL, CADASIL1, CARASIL1, CASIL, FPLD1, IMF2}, MIB1 (MIB E3 ubiquitin protein ligase 1) [NCBI Gene 57534] {aka DIP-1, DIP1, LVNC7, MIB, ZZANK2, ZZZ6}, CDKN2C (cyclin dependent kinase inhibitor 2C) [NCBI Gene 1031] {aka INK4C, p18, p18-INK4C}, CDX2 (caudal type homeobox 2) [NCBI Gene 1045] {aka CDX-3, CDX2/AS, CDX3}, ETFA (electron transfer flavoprotein subunit alpha) [NCBI Gene 2108] {aka EMA, GA2, MADD}, ANO1 (anoctamin 1) [NCBI Gene 55107] {aka DOG1, INDMS, MYMY7, ORAOV2, TAOS2, TMEM16A}, PGR (progesterone receptor) [NCBI Gene 5241] {aka NR3C3, PR}, VIM (vimentin) [NCBI Gene 7431], KRT19 (keratin 19) [NCBI Gene 3880] {aka CK19, K19, K1CS}, GATA3 (GATA binding protein 3) [NCBI Gene 2625] {aka HDR, HDRS}, NKX3-1 (NK3 homeobox 1) [NCBI Gene 4824] {aka BAPX2, NKX3, NKX3.1, NKX3A}, CDH1 (cadherin 1) [NCBI Gene 999] {aka Arc-1, BCDS1, CD324, CDHE, ECAD, LCAM}, TTF1 (transcription termination factor 1) [NCBI Gene 7270] {aka TTF-1, TTF-I}, KIT (KIT proto-oncogene, receptor tyrosine kinase) [NCBI Gene 3815] {aka C-Kit, CD117, MASTC, PBT, SCFR}, CDKN2B (cyclin dependent kinase inhibitor 2B) [NCBI Gene 1030] {aka CDK4I, INK4B, MTS2, P15, TP15, p15INK4b}, TERT (telomerase reverse transcriptase) [NCBI Gene 7015] {aka CMM9, DKCA2, DKCB4, EST2, PFBMFT1, TCS1}, PAX8 (paired box 8) [NCBI Gene 7849] {aka PAX-8}, NF2 (NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor) [NCBI Gene 4771] {aka ACN, BANF, SCH, SWNV, merlin-1}
- **Diseases:** systemic lesions (MESH:D034721), gastric mass (MESH:C536030), tumorigenesis (MESH:D063646), meningothelial neoplasm (MESH:D009369), hepatic and pulmonary metastatic lesions (MESH:D008171), abdominal pain (MESH:D015746), necrosis (MESH:D009336), atypical (MESH:D009437), gastrointestinal metastatic (MESH:D005767), 1p deletion (MESH:C535591), CNS tumors (MESH:D016543), weight loss (MESH:D015431), GIST (MESH:D046152), Extracranial meningioma metastases (MESH:D009362), Malignant meningioma (MESH:D008579)
- **Chemicals:** eosin (MESH:D004801), Hematoxylin (MESH:D006416), everolimus (MESH:D000068338)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

6 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12933254/full.md

## References

12 references — full list in the complete paper: https://tomesphere.com/paper/PMC12933254/full.md

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Source: https://tomesphere.com/paper/PMC12933254