# Peroxisomes and the nervous system: progress and challenges in neuroinflammation and cell-specific functions

**Authors:** Francesca Di Cara, Stéphane Savary

PMC · DOI: 10.3389/fnmol.2026.1745086 · Frontiers in Molecular Neuroscience · 2026-02-11

## Full-text entities

- **Genes:** CAT (catalase) [NCBI Gene 847], PPARA (peroxisome proliferator activated receptor alpha) [NCBI Gene 5465] {aka NR1C1, PPAR, PPAR-alpha, PPARalpha, hPPAR}, IL1B (interleukin 1 beta) [NCBI Gene 3553] {aka IL-1, IL1-BETA, IL1F2, IL1beta}, TNF (tumor necrosis factor) [NCBI Gene 7124] {aka DIF, IMD127, TNF-alpha, TNFA, TNFSF2, TNLG1F}, NOS2 (nitric oxide synthase 2) [NCBI Gene 4843] {aka HEP-NOS, INOS, NOS, NOS2A}, PEX14 (peroxisomal biogenesis factor 14) [NCBI Gene 5195] {aka NAPP2, PBD13A, Pex14p, dJ734G22.2}
- **Diseases:** toxicity (MESH:D064420), intellectual disabilities (MESH:D008607), demyelination (MESH:D003711), X-linked adrenoleuokodystrophy (MESH:C536424), microglial dysfunction (MESH:D006331), peroxisomal diseases (MESH:D018901), cerebral ischemia (MESH:D002545), Alzheimer's disease (MESH:D000544), neurodevelopmental failure (MESH:D051437), neuroinflammation (MESH:D000090862), ZSD (MESH:D015211), neurodegeneration (MESH:D019636), inflammation (MESH:D007249), Alzheimer's and Parkinson's disease (MESH:D010300)
- **Chemicals:** docosanoids (-), hydrogen peroxide (MESH:D006861), eicosanoids (MESH:D015777), PUFAs (MESH:D005231), reactive oxygen species (MESH:D017382), VLCFA (MESH:C017364), lipid (MESH:D008055), linoleic acid (MESH:D019787)
- **Species:** Homo sapiens (human, species) [taxon 9606], Mus musculus (house mouse, species) [taxon 10090], Lactobacillus acidophilus (species) [taxon 1579]

## Full text

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## References

47 references — full list in the complete paper: https://tomesphere.com/paper/PMC12932933/full.md

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Source: https://tomesphere.com/paper/PMC12932933