# Pyogenic Hepatic Abscess as a Complication of Appendicitis: A Case Report

**Authors:** Mohammad AshrafAzimi, Abbas Abdollahi, Mohammad karimi, Homa Jajarmi, Ali Mehri

PMC · DOI: 10.1002/ccr3.72037 · Clinical Case Reports · 2026-02-24

## TL;DR

A rare case of liver abscess caused by appendicitis in a child is reported, highlighting the importance of early imaging and multidisciplinary care for timely treatment.

## Contribution

This case report adds to the limited literature on pyogenic liver abscess as a complication of appendicitis in children.

## Key findings

- An 11-year-old boy presented with fever and neurological symptoms, later diagnosed with pyogenic liver abscess and appendicitis.
- Multidisciplinary care including drainage and appendectomy led to successful treatment and discharge.
- Early imaging and broad differential diagnosis are crucial in pediatric septic shock cases.

## Abstract

Pyogenic liver abscess is a rare and under‐recognized complication of gangrenous or perforated appendicitis in children. Management typically requires a combination of antibiotic therapy and abscess drainage. Although uncommon in the pediatric population, pyogenic liver abscess is more frequently observed in the elderly people. With an aging population, it is increasingly important for young physicians to recognize its clinical presentation and treatment strategies. This report describes an 11‐year‐old boy admitted with fever, impaired consciousness, nausea, and vomiting—initially raising concern for meningitis. A CT scan revealed a hepatic abscess and findings consistent with acute appendicitis. Following multidisciplinary consultation, the patient underwent percutaneous drainage of the liver abscess and an appendectomy. His postoperative course was uneventful, and he was discharged with a liver drain in place. Given the limited reliability of history and physical examination in pediatric patients with septic shock—especially in emergency settings—clinicians must maintain a broad differential diagnosis.

In children with septic shock or atypical presentations, pyogenic liver abscess should be considered as a rare complication of appendicitis. Early imaging and prompt multidisciplinary management, including abscess drainage and targeted antibiotic therapy, are essential for accurate diagnosis, effective treatment, and favorable clinical outcomes.

Pyogenic liver abscess management.

## Linked entities

- **Diseases:** appendicitis (MONDO:0005649), meningitis (MONDO:0021108)

## Full-text entities

- **Genes:** F2 (coagulation factor II, thrombin) [NCBI Gene 2147] {aka PT, RPRGL2, THPH1}, ALB (albumin) [NCBI Gene 213] {aka FDAHT, HSA, PRO0883, PRO0903, PRO1341}, GPT (glutamic--pyruvic transaminase) [NCBI Gene 2875] {aka AAT1, ALT, ALT1, GPT1, SGPT}
- **Diseases:** perforation (MESH:D057112), hepatic damage (MESH:D056486), postoperative infections (MESH:D013530), tuberculosis (MESH:D014376), liver trauma (MESH:D017093), colonic or pelvic infections (MESH:D034161), bacterial infection (MESH:D001424), abdominal discomfort (MESH:D000007), inflammatory bowel disease (MESH:D015212), Job's syndrome (MESH:D007589), hepatic cysts (MESH:D003560), Fungal abscesses (MESH:D009181), septic shock (MESH:D012772), Pyogenic abscesses (MESH:D001922), necrosis (MESH:D009336), septic (MESH:D001170), altered consciousness (MESH:D003244), Amebic abscesses (MESH:D000562), bacterial, viral, or parasitic infections (MESH:D014777), Acute appendicitis (MESH:D001064), portal vein thrombosis (MESH:D012170), thrombosis (MESH:D013927), Phlebitis (MESH:D010689), weight loss (MESH:D015431), Pyogenic liver abscess (MESH:D046290), intra (MESH:D057072), endophthalmitis (MESH:D009877), Leukocytosis (MESH:D007964), Hematogenous infections (MESH:D007239), encephalitis (MESH:D004660), peritonitis (MESH:D010538), jaundice (MESH:D007565), fatigue (MESH:D005221), appendiceal perforations (MESH:D001063), cholecystitis (MESH:D002764), pneumonia (MESH:D011014), pleural effusion (MESH:D010996), biliary disease (MESH:D001660), CGD (MESH:D006105), hemorrhage (MESH:D006470), nausea (MESH:D009325), Yersinia enterocolitica  infection (MESH:D015009), hemochromatosis (MESH:D006432), vomiting (MESH:D014839), ascending cholangitis (MESH:D002761), Fever (MESH:D005334), hematologic malignancies (MESH:D019337), right upper quadrant pain (MESH:D010146), Abscesses (MESH:D000038), inflammation (MESH:D007249), condition (MESH:D020763), liver disease (MESH:D008107), Hepatic Abscess (MESH:D008100), shock (MESH:D012769), trauma (MESH:D014947), hematomas (MESH:D006406), cirrhosis (MESH:D005355), abdominal pain (MESH:D015746), cardiopulmonary disease (MESH:D006323), pancreatitis (MESH:D010195)
- **Chemicals:** oxacillin (MESH:D010068), Cefixime (MESH:D020682), calcium (MESH:D002118), alcohol (MESH:D000438), amikacin (MESH:D000583), rifampin (MESH:D012293), Vancomycin (MESH:D014640), erythromycin (MESH:D004917), phosphorus (MESH:D010758), cefoxitin (MESH:D002440), Metronidazole (MESH:D008795), bilirubin (MESH:D001663)
- **Species:** Entamoeba histolytica (species) [taxon 5759], Aspergillus (genus) [taxon 5052], Homo sapiens (human, species) [taxon 9606], Candida [taxon 1535326], Staphylococcus aureus (species) [taxon 1280], Staphylococcus saprophyticus (species) [taxon 29385], Escherichia coli (E. coli, species) [taxon 562], Klebsiella pneumoniae (species) [taxon 573]

## Full text

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## Figures

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## References

34 references — full list in the complete paper: https://tomesphere.com/paper/PMC12932913/full.md

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Source: https://tomesphere.com/paper/PMC12932913