# Speckle-based X-ray microtomography via preconditioned Wirtinger flow

**Authors:** KyeoReh Lee, Herve Hugonnet, Jae-Hong Lim, YongKeun Park

PMC · DOI: 10.1038/s41377-025-02118-z · Light, Science & Applications · 2026-02-24

## TL;DR

This paper introduces a new X-ray imaging method that improves accuracy and resolution without extra measurements.

## Contribution

The novel contribution is a single-shot, assumption-free X-ray microtomography method using preconditioned Wirtinger flow.

## Key findings

- PWF achieves accurate phase retrieval with a gradient-based algorithm and physical model.
- The method accounts for partial coherence, enabling use with bench-top X-ray sources.
- Experimental results show improved accuracy and resolution compared to conventional speckle tracking.

## Abstract

Three-dimensional quantitative phase imaging has been extensively studied in X-ray microtomography to improve the sensitivity and specificity of measurements, especially for low atomic number materials. However, obtaining quantitative phase images typically requires additional measurements or assumptions, which significantly limit the practical applicability. Here, we present preconditioned Wirtinger flow (PWF) to realize an assumption-free, single-shot, quantitative X-ray microtomography. Accurate phase retrieval is demonstrated using a specialized gradient-based algorithm with an accurate physical model. Partial coherence of the source is taken into account, extending the potential applications to bench-top sources. Improved accuracy and spatial resolution over conventional speckle tracking methods are experimentally demonstrated. The various samples are explored to demonstrate the robustness and versatility of PWF.

## Full-text entities

- **Chemicals:** Lipids (MESH:D008055), soda-lime (MESH:C004569), Ce (MESH:D002563), LuAG (-)
- **Species:** Anchoa mitchilli (bay anchovy, species) [taxon 224718], Cuminum cyminum (cumin, species) [taxon 52462]

## Full text

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## Figures

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## References

4 references — full list in the complete paper: https://tomesphere.com/paper/PMC12932712/full.md

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Source: https://tomesphere.com/paper/PMC12932712