# Stress-induced epigenome changes as a risk factor in the onset of mental disorders

## TL;DR

Stress can cause epigenetic changes that increase the risk of mental disorders like depression and anxiety, especially during critical brain development stages.

## Contribution

This review summarizes how stress affects epigenetic modifiers and gene expression, offering insights into new diagnostic and therapeutic approaches for mental disorders.

## Key findings

- Stress-induced epigenetic changes may explain the rising prevalence of mental disorders.
- Chronic stress impacts brain development and function through altered gene expression.
- Stress effects are most significant during prenatal and early postnatal stages.

## Abstract

The global mental health study has revealed a steady increase in the prevalence of mental disorders worldwide. This trend reflects not only the improvements in diagnostics but also the global population ageing and the intensification of negative environmental impacts that provoke the manifestation of such disorders. One of such primary external causes for mental disorders is stress, which accompanies humans throughout their lives. Stressful exposure, particularly chronic stress, can alter the expression of genes involved in the development, maturation, and functioning of the nervous system, which in turn may provoke the manifestation of mental disorders in susceptible individuals. The effects of stress can explain the increasing prevalence of mental illnesses (depression, anxiety disorders), and their aggravation with age. Stress seems to have the greatest impact during critical periods of brain development: intrauterine and early postnatal stages. The molecular mechanisms mediating the impact of stress on the expression of genes crucial for brain development and function, as well as the list of genes involved, remain poorly understood. In this review, we have attempted to summarize the known information on the influence of stress on the activity of epigenetic modifiers and the state of the epigenome, the expression of target genes, brain development, and changes in behavioral patterns. Studying such mechanisms and the genes involved opens up opportunities for diagnosing mental disorders at a new methodological level and potentially offers new precision approaches to their therapeutic correction at the epigenomic level.