# Beyond cytokine blockade: could CAR-Tregs open a new era of tissue-targeted immune tolerance in psoriatic arthritis? **Authors:** Rubén Queiro, Sara Alonso, Mercedes Alperi PMC · DOI: 10.3389/fimmu.2026.1772369 · Frontiers in Immunology · 2026-02-11 ## Full-text entities - **Genes:** TRBV20OR9-2 (T cell receptor beta variable 20/OR9-2 (non-functional)) [NCBI Gene 6962] {aka CDR3, TCRBV20S2, TCRBV2O, TCRBV2S2O}, CXADRP1 (CXADR pseudogene 1) [NCBI Gene 653108] {aka CAR, CXADRP}, FOXP3 (forkhead box P3) [NCBI Gene 50943] {aka AIID, DIETER, IPEX, JM2, PIDX, XPID}, TNF (tumor necrosis factor) [NCBI Gene 7124] {aka DIF, IMD127, TNF-alpha, TNFA, TNFSF2, TNLG1F}, IL10 (interleukin 10) [NCBI Gene 3586] {aka CSIF, GVHDS, IL-10, IL10A, TGIF}, IL22 (interleukin 22) [NCBI Gene 50616] {aka IL-21, IL-22, IL-D110, IL-TIF, ILTIF, TIFIL-23}, ITGAE (integrin subunit alpha E) [NCBI Gene 3682] {aka CD103, HUMINAE}, CCR6 (C-C motif chemokine receptor 6) [NCBI Gene 1235] {aka BN-1, C-C CKR-6, CC-CKR-6, CCR-6, CD196, CKR-L3}, ADAMTSL5 (ADAMTS like 5) [NCBI Gene 339366] {aka THSD6}, IFNG (interferon gamma) [NCBI Gene 3458] {aka IFG, IFI, IMD69}, CAMP (cathelicidin antimicrobial peptide) [NCBI Gene 820] {aka CAP-18, CAP18, CRAMP, FALL-39, FALL39, HSD26}, CD19 (CD19 molecule) [NCBI Gene 930] {aka B4, CVID3}, CSF2 (colony stimulating factor 2) [NCBI Gene 1437] {aka CSF, GMCSF}, CD69 (CD69 molecule) [NCBI Gene 969] {aka AIM, BL-AC/P26, CLEC2C, EA1, GP32/28, MLR-3}, TGFB1 (transforming growth factor beta 1) [NCBI Gene 7040] {aka CAEND1, CED, DPD1, IBDIMDE, LAP, TGF-beta1}, CD8A (CD8 subunit alpha) [NCBI Gene 925] {aka CD8, CD8alpha, IMD116, Leu2, p32}, IL23R (interleukin 23 receptor) [NCBI Gene 149233] {aka PSORS7}, IL17A (interleukin 17A) [NCBI Gene 3605] {aka CTLA-8, CTLA8, IL-17, IL-17A, IL17, ILA17}, IL6 (interleukin 6) [NCBI Gene 3569] {aka BSF-2, BSF2, CDF, HGF, HSF, IFN-beta-2}, IL23A (interleukin 23 subunit alpha) [NCBI Gene 51561] {aka IL-23, IL-23A, IL23P19, P19, SGRF} - **Diseases:** CRS (MESH:D003398), lupus (MESH:D008180), psoriasis (MESH:D011565), PsA (MESH:D015535), autoimmune diseases (MESH:D001327), neurotoxicity (MESH:D020258), (D2T) disease (MESH:D004194), cardiac inflammation (MESH:D007249), cardiac autoimmunity (MESH:D006331), B-cell malignancies (MESH:D016393), inflammatory bowel disease (MESH:D015212), autoimmune encephalomyelitis (MESH:D004681), Cytokine release syndrome (MESH:D000080424), enthesitis (MESH:D001171), colitis (MESH:D003092), inflammatory arthritis (MESH:D001168) - **Chemicals:** ATMP (-) - **Species:** Homo sapiens (human, species) [taxon 9606] ## Full text _Full body text omitted from this summary view._ Fetch the complete paper as Markdown: https://tomesphere.com/paper/PMC12932465/full.md ## References 15 references — full list in the complete paper: https://tomesphere.com/paper/PMC12932465/full.md --- Source: https://tomesphere.com/paper/PMC12932465