# Editorial: Targeting adipose tissue for the treatment of metabolic alterations

**Authors:** Lorenzo Flori, Bruno Ramos-Molina, Vincenzo Calderone, Alma Martelli

PMC · DOI: 10.3389/fphar.2026.1797423 · Frontiers in Pharmacology · 2026-02-11

## Full-text entities

- **Genes:** Ucp1 (uncoupling protein 1 (mitochondrial, proton carrier)) [NCBI Gene 22227] {aka Slc25a7, Ucp}, Pparg (peroxisome proliferator activated receptor gamma) [NCBI Gene 19016] {aka Nr1c3, PPAR-gamma, PPAR-gamma2, PPARgamma, PPARgamma2}, PRKAA1 (protein kinase AMP-activated catalytic subunit alpha 1) [NCBI Gene 5562] {aka AMPK, AMPK alpha 1, AMPKa1}, Mest (mesoderm specific transcript) [NCBI Gene 17294] {aka Peg1}, Ppargc1a (peroxisome proliferative activated receptor, gamma, coactivator 1 alpha) [NCBI Gene 19017] {aka A830037N07Rik, Gm11133, PGC-1, PPARGC-1-alpha, Pgc-1alpha, Pgc1}, Mir27b (microRNA 27b) [NCBI Gene 387221] {aka Mirn27b, mmu-mir-27b}, Sirt1 (sirtuin 1) [NCBI Gene 93759] {aka SIR2L1, Sir2, Sir2a, Sir2alpha}, Prdm16 (PR domain containing 16) [NCBI Gene 70673] {aka 5730557K01Rik, csp1, mel1}
- **Diseases:** MASLD (MESH:D008107), inflammation (MESH:D007249), metabolic syndrome (MESH:D024821), PCOS (MESH:D011085), cardiovascular disease (MESH:D002318), insulin resistance (MESH:D007333), hepatic steatosis (MESH:D005234), type 2 diabetes (MESH:D003924), obesity (MESH:D009765), adipose tissue deficiency (MESH:D018205), metabolic dysregulation (MESH:D021081), hyperuricemia (MESH:D033461), metabolic disease (MESH:D008659), congenital generalized lipodystrophy (MESH:D052497)
- **Chemicals:** ovarian hormones (-), ibuprofen (MESH:D007052), rosiglitazone (MESH:D000077154), cortisol (MESH:D006854), lipid (MESH:D008055), noradrenaline (MESH:D009638), glucose (MESH:D005947)
- **Species:** Morus alba (white mulberry, species) [taxon 3498], Mus musculus (house mouse, species) [taxon 10090], Homo sapiens (human, species) [taxon 9606], Chrysanthemum indicum (species) [taxon 146995], Prunella vulgaris (common self-heal, species) [taxon 39358]
- **Cell lines:** 3T3-L1 — Mus musculus (Mouse), Spontaneously immortalized cell line (CVCL_0123)

## Full text

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## References

8 references — full list in the complete paper: https://tomesphere.com/paper/PMC12932446/full.md

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Source: https://tomesphere.com/paper/PMC12932446