# The effects of different exercise interventions on clinical outcomes of irritable bowel syndrome and their potential mechanisms: a systematic review and network meta-analysis

## TL;DR

This study reviews how different types of exercise can help manage irritable bowel syndrome symptoms and improve mental health, possibly through gut-immune system effects.

## Contribution

A systematic review and network meta-analysis comparing the efficacy of various exercise interventions for IBS and exploring their immunological mechanisms.

## Key findings

- Moderate-intensity aerobic exercise and Pilates significantly improve depression, anxiety, and IBS-related quality of life.
- Running and aerobic exercise show the best overall efficacy in treating IBS symptoms.
- Exercise interventions may modulate the brain-gut-immune axis, enhancing gut health and reducing inflammation.

## Abstract

Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder characterized by recurrent abdominal pain or discomfort accompanied by altered bowel habits, often alongside psychological symptoms. Increasing evidence suggests that exercise interventions not only alleviate clinical symptoms but may also exert effects through modulation of the gut-immune axis. This study aims to systematically compare the effects of different exercise modalities on symptoms, quality of life, and psychological status in IBS patients, whilst exploring potential immunological mechanisms.

The PubMed, Cochrane Library, EMBASE, and Web of Science databases were systematically searched for literature from inception to June 2025, and conventional Meta-analysis and Web Meta-analysis were performed using RevMan 5.4 and R 4.3.3 software.

Sixteen studies were included, covering interventions such as running, moderate-intensity aerobic exercise, Pilates, yoga, and Baguazhang. Moderate-intensity aerobic exercise and Pilates demonstrated significant effects (P < 0.05) in improving depression and anxiety scores, as well as IBS-SSS and IBS-QOL scores. Running and aerobic exercise showed the best overall efficacy. Mechanistically, exercise interventions may have a synergistic effect on the brain-gut-immune axis by enhancing parasympathetic activity, modulating the HPA axis, improving gut microbiota, strengthening intestinal barrier function, and reducing systemic inflammation. This approach alleviates gastrointestinal symptoms while enhancing mental wellbeing.

Various exercise interventions may improve clinical symptoms and quality of life in patients with irritable bowel syndrome to a certain extent, and may possess potential immunomodulatory effects. As a relatively safe and cost-effective non-pharmacological treatment, exercise holds considerable clinical application potential in the comprehensive management of irritable bowel syndrome.

https://www.crd.york.ac.uk/PROSPERO/, identifier CRD420251132835.