# Safety and oncologic outcomes of total laparoscopic versus abdominal hysterectomy following diagnostic conization for adenocarcinoma in situ and stage IA1 cervical cancer: a multicenter retrospective study

## TL;DR

This study compares laparoscopic and abdominal hysterectomy for early cervical cancer, finding similar cancer outcomes with fewer complications for laparoscopic surgery.

## Contribution

The study provides new evidence that laparoscopic hysterectomy is a safe and effective alternative to abdominal hysterectomy for early-stage cervical cancer.

## Key findings

- TLH had longer operative time but less blood loss and shorter hospital stay compared to TAH.
- TLH showed comparable oncologic outcomes with no recurrences in AIS or stage IA1 cases.
- Only one recurrence was observed in the TAH group for a CIN3 patient.

## Abstract

While simple hysterectomy is the standard treatment for adenocarcinoma in situ (AIS) and stage IA1 cervical cancer, minimally invasive surgery has been increasingly adopted. However, evidence on the safety and efficacy of total laparoscopic hysterectomy (TLH) for these conditions remains limited. We compared the safety and efficacy of TLH and total abdominal hysterectomy (TAH) in patients undergoing simple hysterectomy following diagnostic conization.

We conducted a multicenter retrospective study of 196 patients with cervical intraepithelial neoplasia grade 3 (CIN3), AIS, or stage IA1 cervical cancer who underwent simple hysterectomy following diagnostic conization. Patients were divided into TLH and TAH groups, and intraoperative and postoperative complications and oncologic outcomes were compared.

Operative time was significantly longer in the TLH group, whereas intraoperative blood loss was lower and postoperative hospital stay shorter. No significant difference was noted in severe complication rates, although their patterns varied between groups. Recurrence occurred in one patient (0.5%), a case of CIN3 at the vaginal cuff in the stage IA1 TAH group. No recurrences were observed in patients with AIS or stage IA1 disease in the TLH group.

TLH following diagnostic conization for AIS or stage IA1 cervical cancer demonstrated oncologic efficacy comparable to TAH, with a favorable safety profile. TLH may be a reasonable treatment option for carefully selected patients.

The online version contains supplementary material available at 10.1007/s10147-026-02971-x.