# The Combined Double‐Orifice and Single‐Patch Technique for Partial Atrioventricular Septal Defect in Adults: A Novel Strategy

**Authors:** Hua-Jie Zheng, Rui-Han Xiao, Mao-Ting Ye, Jun Li, Mei Guo, San-Jiu Yu, Yong-Bo Cheng, Wei Cheng

PMC · DOI: 10.1155/cdr/8493694 · Cardiovascular Therapeutics · 2026-02-24

## TL;DR

This study presents a new surgical technique for repairing heart defects in adults, showing it is safe and effective with long-term success.

## Contribution

A novel combined surgical strategy for partial atrioventricular septal defect and tricuspid valve dysplasia in adults is introduced.

## Key findings

- The technique had no operative or late deaths and no moderate/severe tricuspid regurgitation during follow-up.
- Only one patient developed severe mitral regurgitation requiring reoperation.
- The method showed excellent technical reproducibility and durability over a mean follow-up of 5.2 years.

## Abstract

The aim of this study is to share our experience of the combined double‐orifice and single‐patch technique for the correction of partial atrioventricular septal defect (pAVSD) and its associated tricuspid valve dysplasia (TVD).

Between January 2014 and May 2024, 99 patients (age ≥ 18 years) who underwent repair of pAVSD and its associated TVD using the aforementioned strategy were retrospectively analyzed.

The mean aortic cross‐clamp time was 48.5 ± 12.6 min, and the mean cardiopulmonary bypass time was 75.8 ± 13.0 min. Follow‐up was 100% at a mean of 5.2 years (3–8 years). No operative or late deaths occurred. No evidence of mitral stenosis was detected, and only one patient developed a severe MR 2 years after the surgery and underwent reoperation. There was no moderate or severe tricuspid regurgitation during follow‐up. There was neither secondary tricuspid valve repair nor permanent pacemaker implantation among all patients.

The combined double‐orifice and single‐patch technique is a safe, effective, and durable strategy for repair of pAVSD and its associated TVD, demonstrating an excellent technical reproducibility.

## Linked entities

- **Diseases:** partial atrioventricular septal defect (MONDO:0020437)

## Full-text entities

- **Genes:** F2R (coagulation factor II thrombin receptor) [NCBI Gene 2149] {aka CF2R, HTR, PAR-1, PAR1, TR}
- **Diseases:** anterior leaflet prolapse (MESH:D011391), stenosis (MESH:D003251), endocardial cushion defects (MESH:D004694), MR (MESH:D008944), Dysplastic (MESH:D004416), tissue injury (MESH:D017695), Partial atrioventricular septal defect (MESH:C536112), TR (MESH:D014262), mitral stenosis (MESH:D008946), Valve regurgitation (MESH:D006349), annular dilation (MESH:D002311), congenital heart malformations (MESH:D006330), valve prolapse (MESH:D016127), AV block (MESH:D054537), AV nodal injury (MESH:D013611), leaflet abnormalities (MESH:D000014), annular (MESH:D016460), hypothermia (MESH:D007035), ASD (MESH:D006344), Atrioventricular Septal Defect (MESH:C562831), death (MESH:D003643)
- **Chemicals:** polypropylene (MESH:D011126)
- **Species:** Homo sapiens (human, species) [taxon 9606]
- **Mutations:** C-32 C

## Full text

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## Figures

13 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12932322/full.md

## References

14 references — full list in the complete paper: https://tomesphere.com/paper/PMC12932322/full.md

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Source: https://tomesphere.com/paper/PMC12932322