# Phyllodes-predominant prostatic stromal sarcoma concurrent with prostate adenocarcinoma: a case report and literature review

**Authors:** Hongguang Lian, Wenfeng Feng, Ming Zhang, Yanhua Tian, Wenxin Wu, Jinfeng Cui, Yuan Wang

PMC · DOI: 10.3389/fonc.2026.1742518 · Frontiers in Oncology · 2026-02-11

## TL;DR

This paper reports a rare case of a man with two prostate tumors: a phyllodes-predominant stromal sarcoma and prostate adenocarcinoma.

## Contribution

The novelty is the rare co-occurrence of phyllodes-predominant prostatic stromal sarcoma and prostate adenocarcinoma in a single case.

## Key findings

- A 52-year-old man was diagnosed with phyllodes-predominant prostatic stromal sarcoma.
- The patient also had concurrent prostate adenocarcinoma, a very rare combination.
- The case highlights the importance of accurate diagnosis for such rare tumors.

## Abstract

Prostatic stromal sarcoma (PSS) is a rare malignant mesenchymal tumor originating from the specialized stroma of the prostate. It is a heterogeneous tumor, in which a predominantly phyllodes architecture has been documented only in isolated case reports. The co-occurrence of a phyllodes-predominant PSS and prostate adenocarcinoma (PCA) is even more exceptional. Here, we reported a case of a 52-year-old man with the chief complaint of dysuria for 2 months in 2018. Magnetic resonance imaging (MRI) revealed a mass lesion in the left lobe of the prostate. The patient underwent surgical resection, and the pathological examination revealed PSS with a phyllodes-predominant structure accompanied by PCA. We report this rare case to provide valuable clinical information for clinicians and pathologists and to improve the awareness and diagnostic level of this disease.

## Linked entities

- **Diseases:** prostate adenocarcinoma (MONDO:0005082)

## Full-text entities

- **Genes:** CD34 (CD34 molecule) [NCBI Gene 947], EREG (epiregulin) [NCBI Gene 2069] {aka EPR, ER, Ep}, PGR (progesterone receptor) [NCBI Gene 5241] {aka NR3C3, PR}, VIM (vimentin) [NCBI Gene 7431], KLK3 (kallikrein related peptidase 3) [NCBI Gene 354] {aka APS, KLK2A1, PSA, hK3}
- **Diseases:** hemorrhage (MESH:D006470), prostatic intraepithelial neoplasia (MESH:D019048), malignant mesenchymal tumor (MESH:C535700), sarcoma (MESH:D012509), dysuria (MESH:D053159), mass (MESH:C536030), nocturia (MESH:D053158), phyllodes tumor (MESH:D003557), HL (MESH:C538324), prostate cancer (MESH:D011471), pain (MESH:D010146), hematuria (MESH:D006417), Adenocarcinoma (MESH:D000230), Tumor (MESH:D009369), abdominal distension (MESH:D000007), urinary incontinence (MESH:D014549), Prostatic phyllodes tumor (MESH:C549759), STUMP (MESH:C537245), necrosis (MESH:D009336), pyuria (MESH:D011776), PSS (MESH:D011472), metastases (MESH:D009362), Stromal sarcoma (MESH:D046152), thrombus (MESH:D013927)
- **Chemicals:** Mesna (MESH:D015080), Ifosfamide (MESH:D007069), TPSA (-), Epirubicin (MESH:D015251)
- **Species:** Mus musculus (house mouse, species) [taxon 10090], Homo sapiens (human, species) [taxon 9606]
- **Mutations:** P504S

## Full text

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## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12932244/full.md

## References

19 references — full list in the complete paper: https://tomesphere.com/paper/PMC12932244/full.md

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Source: https://tomesphere.com/paper/PMC12932244