# Post-TPS needle placement planning for robotic-assisted LDR seed brachytherapy

**Authors:** Yilun Fan, Xuehe Zhang, Lichen Liu, Changle Li, Chong Yao, Jie Zhao

PMC · DOI: 10.3389/fonc.2026.1730072 · Frontiers in Oncology · 2026-02-11

## TL;DR

This paper introduces a new method to improve robotic seed implantation planning for brachytherapy by optimizing needle paths while ensuring safety and accuracy.

## Contribution

A novel optimization framework that integrates anatomical and robotic constraints into needle placement planning for robotic brachytherapy.

## Key findings

- Simulation studies showed optimized needle placements with minimal deviation from planned seed positions.
- Phantom experiments confirmed the feasibility and accuracy of the optimized trajectories under robotic conditions.

## Abstract

Low-dose-rate (LDR) seed brachytherapy treatment planning systems (TPSs) can generate dose-optimized seed distributions; however, translating these plans into robot-executable needle insertions introduces additional geometric, anatomical, and robotic constraints that may limit clinical feasibility.

This study presents an optimization framework for robotic-assisted LDR seed brachytherapy that refines needle trajectories based on preplanned seed distributions. The framework explicitly incorporates anatomical safety constraints and robotic feasibility requirements while aiming to preserve the original dosimetric quality.

Simulation studies using thoracic and upper abdominal anatomical models show that the proposed method can generate clinically executable needle placements with minimal deviation from the planned seed positions. Phantom experiments further demonstrate the practical feasibility and placement accuracy of the optimized trajectories under robotic operating conditions.

The proposed framework improves the feasibility and reproducibility of robotic-assisted LDR seed implantation in thoracic and related anatomical settings, offering a practical pathway toward safer and more reliable clinical deployment.

## Full-text entities

- **Diseases:** liver metastases (MESH:D009362), thoracic and abdominal tumors (MESH:D000008), thoracic tumors (MESH:D013899), prostate, breast, head and neck, and gynecological malignancies (MESH:D011472), hepatic lesions (MESH:D056486), cancer (MESH:D009369)
- **Chemicals:** Iodine-125 (MESH:C000614960), CY (MESH:D003545), Silicone (MESH:D012828)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

7 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12932239/full.md

## References

34 references — full list in the complete paper: https://tomesphere.com/paper/PMC12932239/full.md

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Source: https://tomesphere.com/paper/PMC12932239