# Association of nutrient supplement use in older adults with chronic diseases: a cross-sectional study

**Authors:** Hua Tian, Jie Chen

PMC · DOI: 10.3389/fnut.2026.1727791 · Frontiers in Nutrition · 2026-02-11

## TL;DR

This study explores how older adults with chronic diseases use nutrient supplements and suggests personalized strategies for better health.

## Contribution

The study identifies associations between nutrient supplement use and specific chronic diseases in older adults.

## Key findings

- Only 11.91% of older participants used nutrient supplements, with calcium being the most common.
- Supplement users were typically women living with family, reporting good health and high life satisfaction.
- Nutrient supplement use was potentially linked to chronic diseases like hypertension and diabetes.

## Abstract

With advancing age, physiological and social changes increase the risk of malnutrition among older adults. Dietary supplements are a prevalent strategy for maintaining nutritional balance, enhancing health, and preventing chronic diseases.

This study analyzed data from 9,986 participants aged 65 and older, drawn from the 2018 Chinese Longitudinal Healthy Longevity Survey (CLHLS), to compare supplement users and non-users. The data were analyzed using Mann–Whitney U test and Chi-square test.

The results revealed that only 11.91% older participants used nutrient supplements, and Calcium was the most used nutrient supplements. The typical user was women without spouses living with family, reporting a moderate lifestyle, high life satisfaction, and good health. There were potential associations between nutrient supplement use with chronic diseases, e.g., hypertension, heart disease, stroke and cerebrovascular disease, diabetes, and pneumonia or bronchitis.

These findings suggest that nutrient supplement strategies should be personalized based on an individual’s chronic diseases. This research provides a crucial evidence base for health professionals to develop targeted interventions aimed at preventing the onset and deterioration of common chronic diseases in older adults.

## Linked entities

- **Diseases:** heart disease (MONDO:0005267), diabetes (MONDO:0005015)

## Full-text entities

- **Diseases:** sarcopenia (MESH:D055948), diseases (MESH:D004194), neurodegeneration (MESH:D019636), mitochondrial dysfunction (MESH:D028361), Alzheimer's and Parkinson's diseases (MESH:D010300), cancer (MESH:D009369), diabetes (MESH:D003920), muscle weakness (MESH:D018908), digestive system tumors (MESH:D004067), overnutrition (MESH:D044343), hypervitaminosis (MESH:D006986), obesity (MESH:D009765), gastric cancer (MESH:D013274), pneumonia (MESH:D011014), overweight (MESH:D050177), Stroke (MESH:D020521), loss of muscle mass (MESH:C536030), deficiencies (MESH:D007153), malnutrition (MESH:D044342), hypertension (MESH:D006973), cardiovascular disease (MESH:D002318), bronchitis (MESH:D001991), cerebrovascular (MESH:D002561), osteoporosis (MESH:D010024), LBM (MESH:D013851), CLHLS (MESH:C562377), heart disease (MESH:D006331), chronic diseases (MESH:D002908)
- **Chemicals:** vitamin D (MESH:D014807), phosphorus (MESH:D010758), salt (MESH:D012492), sugar (MESH:D000073893), Zinc (MESH:D015032), essential fatty acids (MESH:D005228), lycopene (MESH:D000077276), Iron (MESH:D007501), vitamin A (MESH:D014801), copper (MESH:D003300), Vitamin A and D (-), amino acids (MESH:D000596), oil (MESH:D009821), Calcium (MESH:D002118), DHA (MESH:C027493), folate (MESH:D005492)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12932216/full.md

## References

31 references — full list in the complete paper: https://tomesphere.com/paper/PMC12932216/full.md

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Source: https://tomesphere.com/paper/PMC12932216