# Breast mass imaging identification of rare pleomorphic adenoma after follow-up of gastric cancer surgery: a case report

**Authors:** XianJun He, LiLing Lu

PMC · DOI: 10.3389/fonc.2026.1759255 · Frontiers in Oncology · 2026-02-11

## TL;DR

A rare case of breast pleomorphic adenoma is diagnosed after a patient with a history of gastric cancer presents with a breast mass.

## Contribution

The paper presents a case highlighting the diagnostic challenges of pleomorphic adenoma in patients with prior malignancy.

## Key findings

- Pleomorphic adenoma was confirmed in a patient with a history of gastric cancer.
- Imaging and pathological analysis were used to distinguish the benign tumor from malignancy.
- The case emphasizes the importance of accurate preoperative diagnosis to guide appropriate treatment.

## Abstract

This study explores the imaging diagnosis and differential diagnosis of pleomorphic adenoma (PA) of the breast. PA is a rare benign tumor of the breast with a risk of recurrence, though it rarely undergoes malignant transformation. Therefore, extensive local excision is often performed, and a correct preoperative diagnosis of this lesion is important to ensure appropriate surgical treatment. Due to its rarity and nonspecific imaging findings, preoperative diagnosis is challenging and prone to misdiagnosis, especially in patients with a history of other malignancies. We present the case of a patient with a history of gastric cancer (GC) who presented with a breast mass that was pathologically confirmed to be PA. We analyzed the tumor’s imaging and pathological characteristics and discussed the diagnostic strategy.

## Linked entities

- **Diseases:** gastric cancer (MONDO:0001056), pleomorphic adenoma (MONDO:0008401), breast cancer (MONDO:0004989)

## Full-text entities

- **Genes:** PIK3CA (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha) [NCBI Gene 5290] {aka CCM4, CLAPO, CLOVE, CWS5, HMH, MCAP}, CDH1 (cadherin 1) [NCBI Gene 999] {aka Arc-1, BCDS1, CD324, CDHE, ECAD, LCAM}, TP63 (tumor protein p63) [NCBI Gene 8626] {aka AIS, B(p51A), B(p51B), EEC3, KET, LMS}, KIT (KIT proto-oncogene, receptor tyrosine kinase) [NCBI Gene 3815] {aka C-Kit, CD117, MASTC, PBT, SCFR}, ERBB2 (erb-b2 receptor tyrosine kinase 2) [NCBI Gene 2064] {aka CD340, HER-2, HER-2/neu, HER2, MLN 19, MLN-19}, HMGA2 (high mobility group AT-hook 2) [NCBI Gene 8091] {aka BABL, HMGI-C, HMGIC, LIPO, SRS5, STQTL9}, SMN1 (survival of motor neuron 1, telomeric) [NCBI Gene 6606] {aka BCD541, GEMIN1, SMA, SMA1, SMA2, SMA3}, TP53 (tumor protein p53) [NCBI Gene 7157] {aka BCC7, BMFS5, LFS1, P53, TRP53}, KRT7 (keratin 7) [NCBI Gene 3855] {aka CK7, K2C7, K7, SCL}, PLAG1 (PLAG1 zinc finger) [NCBI Gene 5324] {aka PSA, SGPA, SRS4, ZNF912}
- **Diseases:** tenderness (MESH:D063806), ovarian cancer (MESH:D010051), PA of (MESH:D008949), fibroepithelial tumors (MESH:D018225), Lymphoma (MESH:D008223), epithelio-myoepithelial tumor (MESH:D009208), triple-negative (MESH:D064726), benign breast tumor (MESH:D001943), Primary extramammary tumors (MESH:D001932), papillary tumors (MESH:D002291), left breast lesion (MESH:D001941), necrosis (MESH:D009336), Breast mass (MESH:D061325), Leukemia (MESH:D007938), metastases (MESH:D009362), invasive lobular carcinoma (MESH:D018275), Mucinous carcinoma (MESH:D002288), Adenomas (MESH:D000236), TIC (MESH:C566796), GC (MESH:D013274), salivary gland tumors (MESH:D012468), Fibroadenoma (MESH:D018226), pain (MESH:D010146), hereditary syndromes (MESH:D009386), phyllodes tumor (MESH:D003557), melanoma (MESH:D008545), hamartomas (MESH:D006222), swelling (MESH:D004487), lung cancer (MESH:D008175), -grade cancers (MESH:D009369), calcification (MESH:D002114), lactating adenocarcinomas (MESH:D000230)
- **Chemicals:** DCE (-), HE (MESH:D006371)
- **Species:** Homo sapiens (human, species) [taxon 9606], Arachis hypogaea (goober, species) [taxon 3818]
- **Mutations:** E542K, E545K, H1047R

## Full text

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## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12932190/full.md

## References

20 references — full list in the complete paper: https://tomesphere.com/paper/PMC12932190/full.md

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Source: https://tomesphere.com/paper/PMC12932190