# Relationships among perceived stress, anxiety, and well-being in Chinese hospital staff: the mediating role of self-efficacy and the moderating role of empathy

**Authors:** Mingji Li, Guohai Yang, Xianhua Xu, Insoo Oh, Shijie Xu

PMC · DOI: 10.3389/fpsyg.2026.1740682 · Frontiers in Psychology · 2026-02-11

## TL;DR

This study explores how self-efficacy and empathy affect the well-being of hospital staff in China, showing that these factors can help reduce stress and anxiety.

## Contribution

The study identifies self-efficacy as a mediator and empathy as a moderator in the relationship between stress/anxiety and well-being among hospital staff.

## Key findings

- Self-efficacy partially mediates the relationship between perceived stress/anxiety and well-being.
- Empathy enhances the protective effect of self-efficacy on well-being.
- Higher empathy strengthens the positive association between self-efficacy and well-being.

## Abstract

This study aimed to investigate whether self-efficacy mediates the relationship between perceived stress/anxiety and well-being and whether empathy moderates the association between self-efficacy and well-being.

A cross-sectional study was conducted among 543 full-time hospital staff members at Hainan Cancer Hospital in China. Participants completed the Perceived Stress Scale (PSS-10), the Generalized Anxiety Disorder Scale (GAD-7), the General Self-Efficacy Scale (GSES), the Interpersonal Reactivity Index (IRI), and the WHO-5 Well-being Index. A moderated mediation analysis was performed using the SPSS PROCESS Macro.

Mediation analysis indicated that self-efficacy partially mediated the relationship between perceived stress/anxiety and well-being. Empathy moderated the relationship between self-efficacy and well-being, enhancing its protective effects. Specifically, individuals with higher levels of empathy exhibited a stronger positive association between self-efficacy and well-being, highlighting the synergistic role of empathy in mitigating the adverse effects of stress and anxiety.

These findings underscore the importance of interventions targeting self-efficacy and empathy to improve well-being among hospital staff. This study contributes to the growing body of literature on occupational mental health in high-stress healthcare settings.

## Full-text entities

- **Genes:** PSS (Potocki-Shaffer syndrome) [NCBI Gene 780904]
- **Diseases:** compassion fatigue (MESH:D000068376), workplace violence (MESH:D000073397), Anxiety (MESH:D001007), Cancer (MESH:D009369), depression (MESH:D003866), job insecurity (MESH:D007589), GAD-7 (MESH:C537955), Generalized Anxiety Disorder (MESH:C000726808), burnout (MESH:D002055), COVID-19 (MESH:D000086382)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

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## References

62 references — full list in the complete paper: https://tomesphere.com/paper/PMC12932178/full.md

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Source: https://tomesphere.com/paper/PMC12932178