# Does childhood obesity foreshadow a future time-bomb of early and more aggressive cancers?

**Authors:** Jeff M. P. Holly, Katherine Samaras

PMC · DOI: 10.3389/fendo.2025.1674961 · Frontiers in Endocrinology · 2026-02-11

## TL;DR

Childhood obesity may lead to more aggressive cancers later in life, highlighting the need for urgent action to prevent this growing health crisis.

## Contribution

The paper links rising childhood obesity rates to an emerging trend of early-onset cancers, emphasizing the urgency of preventive measures.

## Key findings

- Childhood obesity rates are rising globally despite public health interventions.
- Early-onset cancers are increasing, suggesting a potential link to childhood obesity.
- Long-term studies are needed to confirm the connection, but action is urgent to prevent future health crises.

## Abstract

There has been a global explosion in the prevalence of childhood obesity with 20% of children worldwide now growing up with excess weight and, despite many calls for interventions to redress the costs to health and society, rates continue to rise. It has also recently been observed that there is a global trend with the incidence of early-onset cancers, diagnoses prior to age 50, increasing. We outline the different lines of evidence implicating that these two trends may be linked. Conclusive proof will only be obtained when longitudinal studies, initiated after the current surge in childhood obesity, mature. This will require decades, however, due to the long time-lag between exposure and cancer presentation it would then be too late to avoid a time-bomb of early cancers. This adds considerable urgency to the calls for more effective action to prevent the current epidemic of childhood obesity. The obesity epidemic is driven by an obesogenic food system to which children are particularly vulnerable. Protecting children will require broad multisector coalitions to enable sets of mutually reinforcing policies such as front-of-pack food labelling, restrictions on the ubiquitous marketing, food taxes, subsidies and mandated healthy school meal programs.

## Full-text entities

- **Genes:** INS (insulin) [NCBI Gene 3630] {aka IDDM, IDDM1, IDDM2, ILPR, IRDN, MODY10}, Pik3r1 (phosphoinositide-3-kinase regulatory subunit 1) [NCBI Gene 18708] {aka PI3K, p50alpha, p55alpha, p85alpha}, Pkm (pyruvate kinase, muscle) [NCBI Gene 18746] {aka Pk-2, Pk-3, Pk3, Pkm2}
- **Diseases:** diffuse large B-cell lymphoma (MESH:D016403), infection (MESH:D007239), multiple myeloma (MESH:D009101), diabetes (MESH:D003920), cervical adenocarcinomas (MESH:D000230), Cancer (MESH:D009369), cancer of the esophagus (MESH:D004938), prediabetes (MESH:D011236), excess weight (MESH:D015431), renal cell carcinoma (MESH:D002292), asthma (MESH:D001249), Injuries (MESH:D014947), Diseases (MESH:D004194), intestine, vulva, penis (MESH:D010409), type 2 diabetes (MESH:D003924), steatotic liver disease (MESH:D008107), inflammatory (MESH:D007249), prostate cancers (MESH:D011471), malignant melanoma (MESH:D008545), Obesity (MESH:D009765), breast and cervical cancers (MESH:D001943), adiposity (MESH:D018205), metabolic disturbances (MESH:D024821), gastrointestinal cancer (MESH:D005770), hypertension (MESH:D006973), meningioma (MESH:D008579), occult (MESH:D005596), colorectal and endometrial cancers (MESH:D016889), death (MESH:D003643), carcinogenic (MESH:D011230), adenoma (MESH:D000236), extra-hepatic bile-duct, (MESH:D001650), type 1 diabetes (MESH:D003922), overweight (MESH:D050177), colorectal cancer (MESH:D015179), oral cavity cancers (MESH:D009062), carcinogenesis (MESH:D063646)
- **Chemicals:** lactate (MESH:D019344), glucose (MESH:D005947)
- **Species:** Mus musculus (house mouse, species) [taxon 10090], Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12932159/full.md

## References

84 references — full list in the complete paper: https://tomesphere.com/paper/PMC12932159/full.md

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Source: https://tomesphere.com/paper/PMC12932159