# Impact of sodium alginate energy gel on the marathon performance of amateur runners: a randomized controlled study

**Authors:** Peng Zhang, Zhongke Gu, Kai Xu, Yanrong Zhao, Gangrui Chen, Jiansong Dai

PMC · DOI: 10.3389/fphys.2026.1746392 · Frontiers in Physiology · 2026-02-11

## TL;DR

This study compared sodium alginate energy gels to traditional gels in amateur marathon runners, finding better blood glucose stability and pace consistency with the sodium alginate gels.

## Contribution

The study introduces sodium alginate energy gels as a novel alternative for managing glycemic stability during marathons.

## Key findings

- Sodium alginate gels reduced blood glucose fluctuations in advanced runners during specific marathon segments.
- Elite runners showed improved pace stability with sodium alginate gels compared to traditional gels.
- No significant improvement in overall race performance was observed with sodium alginate gels.

## Abstract

Sodium alginate hydrogel can encapsulate high-sugar substances, alleviate gastric discomfort, accelerate gastric emptying speed, and gradually expand in the small intestine while slowly releasing carbohydrates. This study aimed to evaluate the impact of sodium alginate energy gels versus traditional energy gels on glycemic stability and running performance in marathoners.

Eighty-one amateur runners were selected and randomly assigned to four groups: elite sodium alginate energy gel (ES), elite traditional energy gel (ET), advanced sodium alginate energy gel (AS), and advanced traditional energy gel (AT). All participants utilized CGM devices for 1 week prior to the race to establish baseline glucose levels. During the marathon, carbohydrates were administered at a rate of 60 g per hour. Individual pace and glucose data were normalized to account for variations among runners of differing skill levels.

The completion times for both runner groups at the same level showed no notable differences. In the AS group, blood glucose fluctuation range during the 11–20 km and 31–40 km segments were found to be lower compared to the AT group. Additionally, the ES group exhibited a significantly smaller percentage change in speed over the 1–42 km segment compared to the ET group, while the AS group also demonstrated a notably lower percentage change in speed for the 1–20 km segment relative to the AT group.

While sodium alginate energy gel did not improve average race pace or final competition results, it significantly enhanced blood glucose stability for advanced runners in specific race segments. Additionally, it improved pace stability for elite runners throughout the race and for advanced runners during the first half. These findings suggest that sodium alginate energy gels may have potential benefits in promoting metabolic regulation during endurance exercise.

## Full-text entities

- **Genes:** SLC5A1 (solute carrier family 5 member 1) [NCBI Gene 6523] {aka D22S675, NAGT, SGLT-1, SGLT1}, MBTPS1 (membrane bound transcription factor peptidase, site 1) [NCBI Gene 8720] {aka CAOP, PCSK8, S1P, SEDKF, SKI-1}, SLC2A5 (solute carrier family 2 member 5) [NCBI Gene 6518] {aka GLUT-5, GLUT5}, APP (amyloid beta precursor protein) [NCBI Gene 351] {aka AAA, ABETA, ABPP, AD1, APPI, CTFgamma}, INS (insulin) [NCBI Gene 3630] {aka IDDM, IDDM1, IDDM2, ILPR, IRDN, MODY10}, GCG (glucagon) [NCBI Gene 2641] {aka GLP-1, GLP1, GLP2, GRPP}
- **Diseases:** organ damage (MESH:D000092124), systemic (MESH:D015619), bloating (MESH:C535647), hypoglycemia (MESH:D007003), gastrointestinal discomfort (MESH:D005767), glycogen (MESH:D006008), nausea (MESH:D009325), fatigue (MESH:D005221), diarrhea (MESH:D003967), Inflammatory (MESH:D007249), diabetic (MESH:D003920)
- **Chemicals:** fructose (MESH:D005632), Glucose (MESH:D005947), beta-D-mannuronic acid (MESH:C008324), CPT PRO (-), Carbohydrate (MESH:D002241), water (MESH:D014867), glycogen (MESH:D006003), alpha-L-guluronic acid (MESH:C007896), Blood Glucose (MESH:D001786), sugar (MESH:D000073893), chitosan (MESH:D048271), Alginate (MESH:D000464), polysaccharide (MESH:D011134), pectin (MESH:D010368), cortisol (MESH:D006854), monosaccharides (MESH:D009005), adrenaline (MESH:D004837)
- **Species:** Homo sapiens (human, species) [taxon 9606], Musa acuminata (banana, species) [taxon 4641]

## Full text

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## Figures

8 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12932157/full.md

## References

54 references — full list in the complete paper: https://tomesphere.com/paper/PMC12932157/full.md

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Source: https://tomesphere.com/paper/PMC12932157